Functions of T Cells in Host Defense Flashcards
What is the main signal DCs release to induce Th1? What signals does it produce?
IL-12 –> STAT4 and Tbet –> Th1
makes: INF gamma and LTalpha
What cells and antibody do Th1 cells stimulate?
macrophages
IgG
(intracellular defense)
What is the signaling pathway for DCs to induce Th2 cell?
APC –> IL-4 –> STAT6 –> GATA3 –> Th2
What signals do Th2 cells produce?
What cells/abs do they stimulate?
IL-4, IL-5, IL-13
mast cells, eosinophils, IgE
What cytokine from regulatoryT cells induces T cell proliferation and regulatory T cell survival?
IL-2
What cytokine from CD4 and CD8 t cells and NK cells induces activation of macrophages?
interferon gamma
What cytokine induces B cell switching to IgE?
What cells is it from?
IL-4
CD4+ T cells and mast cells
What cytokine activates eosinophils?
IL-5
What cytokine stimulates acute inflammation when presented from Th17 cells?
IL-17
What is the signaling pathway to induce Th17 cells?
APC –> TGFbeta and IL-6 –> STAT3 –> RORgammaT –> Th17
What cytokines do Th17 cells produce?
IL-17A and IL-17F
IL22
IL21
CCL20
What is the signaling path to induce a Treg cell?
APC –> IL-2 and TGF-beta –> STAT6 –> FoxP3 –> Treg
How do NK cells help in development of Th1 cells?
release IFN gamma which couples w/ IL-12 from DCs –> stat1, stat4 and Tbet
What is the effect of Th1 cells producing IFN-gamma?
self-amplifies it becoming Th1 and inhibits development into Th2 and Th17
Where is the CD40L gene located?
X-chromosome
