Function of White Blood Cells Flashcards
What cells are apart of innate immunity?
Rapid response: - Dendritic cells - Mast cells - Macrophages - Neutrophils - Eosinophils - Basophils - NK cells
What cells are apart of Adaptive immunity?
Secondary response: -B cells -T cells
what are the functions of WBC?
They are able to both identify and eliminate invading pathogens - first line of defense against stuff = non-specific - trigger an inflammatory response - recognize different types of pathogens using a PRR - rapid onset
What are the two categories that leukocytes are broken up into?
1) granulocytes = segmented nucleus 2) agranulocytes = intact nucleus
What are neutrophils, eosoinophils and basophils?
Granulotcytes = have secretory granules
What are agranulocytes?
- Lymphocytes - monocytes
Where do all WBC originate?
Bone marrow -> Hematopietic cells -> common myleoid cells = leukocytes
What is this?
Small lymphocyte (adaptive)
What is this?
Large lymphocyte (adaptive)
What is this?
Neutrophil
What is this??
Band neutrophil
What is this?
Monocytes: -Phagocytic indented nucleus - slightly larger than lymphocytes -life span of 20-40hrs in blood = precursor to macrophages
What is thissss?
Eosinophil: Granule proteins: Myelin basic protein Function: Controlling parasitic infestation - possible roles against bacterial and viral infections Produces mediators that perform different killing abilities
What is this?
Basophil: Play a major role in allergic and inflammatory reactions -surface receptors for IgE -limited phagocytic and bactericidal activity
What WBC is usually the highest % in blood?
Neutrophils
What is this?
Mast cell = originates in the tissue
What three WBC originate in the tissue?
Dendritic cells Mast cells Macrophages
What are the three killing mechanisms of neutrophils?
- Phagocytic-phagolysosome 2. Secretory granules with antibacterial products 3. NETs-core DNA elements immobilize bacteria
What is the granule protein of eosinophils?
Granule proteins: Myelin basic protein
What is this?
Macrophages: Highly phagocytic -produce cytokines - signalling and amplification of immune response -Antigen presenting cells - initiate immune response
What are phagocytes?
Macrophages, monocytes, neutrophils Main three functions: 1) Trapping, engulfment + destruction of pathogens 2) cytokine secretion = inducing local and systemic effects 3) Antigen presenting + processing (macrophages + dendritic cells)
How do innate cells recognize pathogens?
Pattern-recognition receptors (PRRs) detect microbes by binding to pathogen-associated molecular patterns (PAMPs) - PAMPs bind to PRR on innate cells that can facilitate phagocytosis or induce cell signalling and pro-inflammatory or interferon cytokine signalling
What are PAMPs?
They are unique microbial molecules shared by groups of related microbes not found associated with mammalian cells
What presents PAMPs to PRRs?
- Macrophages - Dendritic cells - granulocytes - endothelial cells - mucosal epithelial cells
