Fouty: Asthma Flashcards
young
diaphoretic
resp. distress
asthma
chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness, and an underlying inflammation
asthma
people with this have airways that are sensitive to things others are not
asthma
airways narrow too much and too easily (hyperreactive)
chronic inflammation of airways
asthma
increased tone of bronchial smooth muscle
inflammation/edema of airways
asthma
Episodic wheezing, dyspnea, chest tightness
With or without known triggers (cold, allergens, exercise, etc.)
Symptoms worse at night
diagnose asthma
Presence of airflow obstruction on spirometry
Usually reversible, but can be non-reversible when advanced
OR
Positive methacholine challenge test
diagnose asthma
high normal serum eosinophils
increased exhaled NO
people with asthma
Bronchoconstriction and inflammation due to pollen, dust, smoke, cats…etc
asthma
asthma
demonstrate obstruction or provoke it to confirm what
asthma
not an increase in TLC, but does have gas trapping
asthma
Increase in smooth muscle mass and tone
Lumen is narrow
asthma
acute infection or exposure from chemical; increased inflammation of smooth muscle; more narrowing of lumen
status asthmaticus
_____ exacerbations lead to hyperinflation
asthma
_______Can Detect Asthma In People Who Are Not Acutely Having Bronchospasm
bronchoprovocation
how to provoke asthma attack
methacholine/histamine
Increase the tone in the bronchi are activation of Ach (cholinergic) binding M3(Gq)—-Ca2+) calcium is released in the airway smooth muscles and causes ______
vasoconstriction
Increase in smooth muscle—–increases tone at baseline and reactivity to things that cause vasoconstriction (triggers); more mucus (blue)
remodeling of airway
Combination of genetics, environment (how clean or dirty it was growing up), obesity, dysregulated immunity
people who get asthma
excess Th2 activity (IL-4, IL-5, IL-13) leads to what 3 things
atopy
allergies
asthma
this type of asthma mediated by IL-4, IL-5, IL-13
allergic eosinophilic asthma