Formulas Flashcards by ashley portale

Q

Volume of Distribution

A

Vd = dose/Co

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Q

Clearance

A

CL = 0.693 x Vd/half life

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Q

First Order Metabolism

A

V = Rate of Drug Metabolism = Vmax [C] / Km + [C]

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Q

Zero Order Metabolism

A

V = Vmax [C] / [C]

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Q

Total Clearance

A

CLtotal = CLhepatic + CLrenal + CLpulmonary + CLother

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Q

Dosing Rate for Css

A

dosing rate = (target Cplasma) (CL) / F

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Q

Loading Dose

A

Loading dose = Vd(desired Css plasma) / F

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Q

Dose Adjustment

A

new dosage = Vd(C2-C1)

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Q

Rate of Infusion

A

Ro = Css x CLt

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Q

CLt

A

clearance during half life

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Q

CL

A

clearance

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Q

F

A

Bioavailability

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Q

Vmax

A

maximum velocity

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Q

Km

A

constant of enzyme involved

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Q

at 50% Css

A

t = half life

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Q

at 75% Css

A

t = 2 x half life

Q

at 87.5% Css

A

t = 3 x half life

Q

at 90% Css

A

t = 3.3 x half life

Q

at 93.75% Css

A

t = 4 x half life

Q

at 96.875% Css

A

t = 5 x half life

Q

C2

A

target plasma concentration

Q

C1

A

reported plasma concentration