Formulas Flashcards
1
Q
Volume of Distribution
A
Vd = dose/Co
2
Q
Clearance
A
CL = 0.693 x Vd/half life
3
Q
First Order Metabolism
A
V = Rate of Drug Metabolism = Vmax [C] / Km + [C]
4
Q
Zero Order Metabolism
A
V = Vmax [C] / [C]
5
Q
Total Clearance
A
CLtotal = CLhepatic + CLrenal + CLpulmonary + CLother
6
Q
Dosing Rate for Css
A
dosing rate = (target Cplasma) (CL) / F
7
Q
Loading Dose
A
Loading dose = Vd(desired Css plasma) / F
8
Q
Dose Adjustment
A
new dosage = Vd(C2-C1)
9
Q
Rate of Infusion
A
Ro = Css x CLt
10
Q
CLt
A
clearance during half life
11
Q
CL
A
clearance
12
Q
F
A
Bioavailability
13
Q
Vmax
A
maximum velocity
14
Q
Km
A
constant of enzyme involved
15
Q
at 50% Css
A
t = half life
