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Pharmacology > Cholinergic Agonists and Antagonists > Flashcards

Cholinergic Agonists and Antagonists Flashcards

1
Q

Acetylcholine

A

Agonist - DA

  • Decreases HR and BP
  • therapeutically of no importance
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2
Q

Bethanechol

A

Agonist - DA

  • Increases intestinal motility and tone
  • Stimulates detrusor muscles of the bladder
  • used often for non obstructive urinary retention (postpartum, post-op)
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3
Q

Carbachol

A

Agonist - DA

  • pupillary contraction
  • decreased IOP
  • treatment of glaucoma
  • high potency, long duration of action
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4
Q

Pilocarpine

A

Agonist -DA

  • lowers IOP immediately (good for emergency situations)
  • increases drainage of aqueous humor
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5
Q

Cevimeline

A

Agonist -IAR

  • used for treatment of dry mouth and lack of tears
  • treatment of Sjogrens syndrome
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6
Q

Edrophonium

A

Agonist - IAR

  • increases muscle strength
  • used in diagnosis of myasthenia graves (tension test)
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7
Q

Physostigmine

A

Agonist - IAR

  • increases intestinal and bladder motility
  • produces miosis, spasm and decreases IOP
  • antidote for atropine, etc.
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8
Q

Neostigmine

A

Agonist - IAR

  • stimulates bladder and GI tract
  • antidote for tubocurarine
  • treatment of myasthenia gravis
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9
Q

Pyridostigmine

A

Agonist - IAR

  • cholinesterase inhibitor
  • chronic management of myasthenia gravis
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10
Q

Ambenomium

A

Agonist - IAR

  • cholinesterase inhibitor
  • chronic management of myasthenia gravis
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11
Q

Tacrine

A

Agonist - IAR

  • delays progression of Alzheimer’s disease
  • been replaced b/c of its hepatotoxicity
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12
Q

Donepezil

A

Agonist - IAR

-delays progression of Alzheimer’s disease

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13
Q

Rivastigmine

A

Agonist - IAR

-delays progression of Alzheimer’s disease

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14
Q

Galantamine

A

Agonist - IAR

-delays progression of Alzheimer’s disease

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15
Q

Echothiophate

A

Agonist - IAI

  • open-angle glaucoma treatment
  • not a first line treatment
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16
Q

Pralidoxime

A

Agonist - Reactivation of AChE inhibitor

-Reactivation of AChE

17
Q

Atropine

A

Antagonist

  • antimuscarinic
  • antispasmodic (relaxes GI and bladder)
  • antidote for cholinergic agonists
  • antisecretory (for surgery)
18
Q

Scopolamine

A

Antagonist

  • antimuscarinic
  • prevention of motion sickness
  • blocks short term memory
  • adjunct w/anesthetic procedures
19
Q

Ipratropium

A

Antagonist

  • antimuscarinic
  • treatment of asthma for pts who cannot take adrenergic agonists
  • mangement of bronchospasm (COPD, chronic bronchitis, emphysema)
20
Q

Tiotropium

A

Antagonist

  • antimuscarinic
  • treatment of asthma for pts who cannot take adrenergic agonists
  • mangement of bronchospasm (COPD, chronic bronchitis, emphysema)
21
Q

Tropicamide

A

Antagonist

  • antimuscarinic
  • ophthalmic use of madrases and cycloplegia
22
Q

Cyclopentolate

A

Antagonist

  • antimuscarinic
  • ophthalmic use of madrases and cycloplegia
23
Q

Benztropine

A

Antagonist

  • antimuscarinic
  • useful as adjuncts with other antiparkinsons agents
24
Q

Trihexyphenidyl

A

Antagonist

  • antimuscarinic
  • useful as adjuncts with other antiparkinsons agents
25
Q

Darifenacin, fesoterodine, oxybutynin, solifenacin, tolerodine and triopsium chloride

A

Antagonist

  • antimuscarinic
  • treatment of overactive urinary disease
26
Q

Nicotine

A

Antagonist

  • ganglionic blocker
  • no therapeutic benefit
27
Q

Mecamlylamine

A

Antagonist

  • ganglionic blocker
  • lowers BP in emergency situations (IV)
28
Q

Curare

A

Antagonist - NMB

  • non depolarizing
  • used as an adjunct with anesthesia to relax skeletal muscles
  • intubation, ortho surgery
29
Q

Tubocurnine

A

Antagonist - NMB

  • non depolarizing (competitive)
  • used as an adjunct with anesthesia to relax skeletal muscles
  • intubation, ortho surgery
30
Q

Succinylcholine

A

Antagonist - NMB

  • depolarizing
  • useful for rapid endotracheal intubation
  • used w/electroconvulsive shock treatment

Pharmacology (4 decks)

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