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dermatology > formative 1 > Flashcards

formative 1 Flashcards

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Dermatology Board Prep flashcards
1
Q

function of fibroblasts

A

collagen synthesis

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2
Q

highly metabolically active small cuboidal cells, which layer

A

basal layer

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3
Q

layer assoc with odland bodies

A

granular

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4
Q

layer assoc with polyhedral cells with lots of desmosomes

A

prickle cell layer

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5
Q

layer assoc with corneocytes

A

keratin layer

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6
Q

direct cell killing hyersensitivity reaction

A

type II

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7
Q

immune complex mediated hypersensitivity reaction

A

type III

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8
Q

which layer is most metabolically active

A

basal

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9
Q

embryolocial migration of melanocytes

A

melanocytes migrate to skin from neural crest

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10
Q

langerhan cells

A

migrate through epidermis and dermus + travel via lymphatic to present antigens to lymph nodes

they are formed in bone marrow

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11
Q

systems important in maintaining good circulation in the lower limb

A

muscle pump
venous valves
pulse pressure

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12
Q

what carries out vit D metabolism

A

keratinocytes

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13
Q

responsible for epidermal proliferation

A

basal cells

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14
Q

tensile strength

A

collagen

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15
Q

what percentage of GP consultations are skin problems

A

15-23%

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16
Q

fibroblasts, lymphatics and ground substance are present in what layer of the skin

A

dermis

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17
Q

where are hemi desmosomes found

A

epidermal junction

18
Q

MoA of impedin virulence factor? modulin?

A

enables the organism to avoid host defense mechanisms

modulin = causes damage to host INdirectly

19
Q

how long does it take for cells to migrate from the basal layer to the keratin layer

A

28days

20
Q

when do cells lose their nuclei

A

granular, is complete by keratin layer

21
Q

how many cells thick in the granular layer

A

2-3

22
Q

developmental growth pattern of skin follows what

A

blaschkos lines

23
Q

lunula of nail

A

white bit proximal part of nail under skin

24
Q

component of MRSA strain which causes necrotising fasciitis

A

panton valentine leukocidin

25
Q

nails

A

hard densely packed keratin similar to hair
finger nails grow at 0.1mm a day
toe nails grow slower
commonly affected by disease

26
Q

deficient enzyme in acute intermittent porphyria

A

PBG deaminase

porphobilinogen deaminase

27
Q

commonest sweat gland on face

A

eccrine glands

28
Q

which sweat glands play a role in temp regulation

A

eccrine

moisten palms/soles for grip

29
Q

which sweat glands are involved in scent

A

apocrine - P for pits

30
Q

Meissners corpuscles

A

vibration sensation

31
Q

pacinian corpuscles

A

Pressure sensation

32
Q

involuting phase of hair grow

A

catagen

33
Q

stages of hair growth

A

anagen -> catagen -> telogen

growing -> involuting - > resting

34
Q

deficient enzyme in erythropoeitic protoporphyria

A

ferrochelatase

build up of protoporphyrin IV

35
Q

where are sebaceous glands not found

A

palms, soles and dorsum

sebaceous = holocrine

36
Q

which of apocrine and eccrine are apart of the pilosebaceous unit

A

apocrine = part of pilosebaceous unit

eccrine not

37
Q

what controls eccrine glands

A

sympathetic nervous system

regulate body temo by secretinng salty solution
highest conc on palms + soles

38
Q

main fibres of dermis? what binds them?

A

collagen + elastin

bound together by ground substance

39
Q

where are merkel cells found, function?

A

basal layer

slow adapting mechanoreceptors which are important in ligth touch sensation

40
Q

langerhans cells

A

antigen presenting cel whihc belongs to fam of dendritic cells

presents antigens to naive T cells present in the regional lymph nodes in order to iniate adaptive immune response

41
Q

in what part of the body is there an extra layer of the epidermis

A

palms + soles

stratum lucidum - located between keratin + granular layer

dermatology (10 decks)

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