Forces Acting Across Membranes Flashcards

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1
Q

4 main functions of membrane proteins

A
  1. receptors
  2. transporters
  3. enzymes
  4. maintenance of cell structure
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2
Q

protein content of different membranes

A

myelin - 18% proteins
plasma membrane - 50%
inner mitochondrial membrane - 75%

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3
Q

receptors

A
  • integral membrane protein

- extracellular signal –> intracellular response

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4
Q

transporters

A
  1. channel proteins

2. carrier proteins (horseshoe shaped - larger molecules)

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5
Q

porin

A

protein channel that is always open and filled with water so that small water soluble molecules can pass through.

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6
Q

dystrophin protein

A

anchors cell membrane to intracellular cytoskeleton, is located on the inside of the cell membrane
- loss of these lead to DMD

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7
Q

5 mechs of movement btw compartments

A
  1. endo/exocytosis
  2. diffusion
  3. mediated transport
  4. osmosis
  5. filtration (not really related)
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8
Q

why don’t give patient water through IV?

A

once it has entered circulation, water will move into nearby tissue to regain equal concentration inside and out of vessel wall and cause the tissue to rupture.
It would be good if solutes can move out of the cell into the blood, but membrane is not permeable to those, and water moved in from the plasma to the cells instead.

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9
Q

normal plasma osmolarity and tonicity

A

285 milliosmoles/L

- since most of these are non penetrating, osmolarity and tonicity in the ECF is the same

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10
Q

molarity vs osmolarity vs tonicity

A

molarity: molecules/L
osmolarity: particles/L
tonicity: like osmolarity, but only non penetration particles

tonicity is the most important because it can actually determine the cell volume

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11
Q

an example of an isotonic solution commonly used

A

0.1% saline (150 mM)

will differentiate into 300 mM

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