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VMPM > Foot and Mouth Disease - Integument > Flashcards

Foot and Mouth Disease - Integument Flashcards

1
Q

Virion Properties FMD

A

Picornavirus
-Naked
-30 nm
+ssRNA (7-8kb)
Icosahedral
Genome Infectious

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2
Q

FMD Disease

A

Highly contagious vesicular disease
-Infects usually inapparent
-Cattle and Swine most severely affected
-Sheep/goats inapparent

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3
Q

Serotypes

A

7 Serotypes
-OAC (Europe, Asia, Africa, and South America)
-SAT 1,2,3 (Africa)
-Asia 1
Subtypes w/in each = Topotypes

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4
Q

Disease Mortality

A

Highly fatal in young (Myocarditis and low milk)
Low mortality in adults

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5
Q

Disease Character

A

Fever
Blister sores on tongue, lips, mouth, teats, and hooves
Majority recover but weakend

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6
Q

Genus - Family

A

Aphthovirus - Picornaviridae

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7
Q

Clinical presentation (cattle, goats, sheep)

A

Vesicles appear 2 - 8 days PI
-Oral, feet, teats, udder
Virus shed from lungs 24 hours before signs
Abortions from stress

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8
Q

Persistent infections

A

Swine - 1 month
Cattle - 9 months - 2 years
Goats/sheep - 1 year

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9
Q

FMD Infects

A

Cattle, sheep, swine

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10
Q

Swine Vesicular disease

A

Swine

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11
Q

Vesicular stomatitis

A

Cattle, sheep, swine, horse

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12
Q

Vesicular exanthema of swine

A

Swine

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12
Q

FMD in Swine

A

1st sign - lameness
Lesions less conspicuous
10^3 more viral shedding
Persistence 1 month

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13
Q

FMD Control and prevention

A

Transmission by contact and aerosol
Feedstuff, fomites
Retains infectivity for months
Airborne transmission 100 miles

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14
Q

Diagnosis

A

Differentiate from other vesicular diseases
-Multiplex PCR
-EM, VI, Serology
Control - quarantine, test, exterminate herd

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15
Q

Control in Endemic

A

-Vaccinate with killed product - Based on FMD WT
-Periodic evaluation due to AG changes in WT

16
Q

Disposal

A

Incineration
Burial - Municipal solid waste

17
Q

Zoonitic

A

Humans transiently infected
-Vesicles in mouth
-upper respiratory - spread to animals

VMPM (14 decks)

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