Arboviruses - General Flashcards
1
Q
Arbo - Genome
A
RNA always
2
Q
Disease
A
-Site of repliation
-Viremia
-Immune response
3
Q
Cycle
A
- Replication in lymphoid/macrophages
- Amp / viremia - Seeding target organs (not site of shedding)
- Blood - entry/exit
Seroprevalence»_space;»> Disease
4
Q
Pathogenesis
A
Fever/malaise = Flu
Cytokine (not target organ)
Virus replication in Target organs -> Clinical disease
5
Q
Lymphocytes macrophages
A
Fever - common
6
Q
Vascular Endothelium
A
Rash, hemmorrhages, Thrombo, Immuno - Dengue
7
Q
Brain
A
Encephalitis - VEEV, WNV
8
Q
Liver
A
Hepatitis - Yellow
9
Q
Muscle
A
Myalgias - Ross
10
Q
Fetus
A
Malformed - Cache Valley
11
Q
CNS sings
A
Not infectious - Brain contains infectious virus
12
Q
Viremia to infect
A
10^5
13
Q
EEV WEV WVN Viremia
A
10^4
14
Q
VEEV Viremia
A
10^6-7
15
Q
When do infections occur
A
Late summer/early fall
