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Clinical > Focal Lesions in the Liver > Flashcards

Focal Lesions in the Liver Flashcards

1
Q

What are the benign focal lesions in the liver?

A

Haemangioma
Focal nodular hyperplasia
Adenoma
Liver cysts

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2
Q

What are the malignant focal lesions in the liver?

A 
1. Primary liver cancers:
Hepatocellular carcinoma
Cholangiocarcinoma
- Fibrolamellar carcinoma
- Hepatoblastoma, inc. angiosarcoma and haemangioendothelioma
  1. Metastases from elsewhere
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3
Q

How common are haemangiomas?

A

Commonest liver tumour, with prevalence being higher in females

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4
Q

Features of haemangiomas?

A

Usually a single, small hypervascular tumour that is contained in a well-demarcated capsule; they are usually asymptomatic

Hypervascular refers to the high conc. of blood vessels, enabling rapid growth

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5
Q

Diagnostic methods of haemangiomas?

A

Ultrasound shows an echogenic spot that is well-demarcated

CT scan shows venous enhancement, from periphery to centre

MRI scan shows a high intensity area

There is no need for FNA (Fine Needle Aspiration - biopsy)

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6
Q

How are haemangiomas treated?

A

No need for treatment

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7
Q

What is Focal Nodular Hyperplasia (FNH)?

A

Benign nodule formation of normal liver tissue; there is a hyperplastic response to abnormal arterial flow

It can occur as a congenital vascular anomaly and has an assoc. with Osler-Weber-Rendu syndrome (autosomal dominant genetic disorder that leads to abnormal blood vessel formation) and with liver haemangiomas

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8
Q

Appearance of FNH?

A

Classically, a central scar containing a large artery, with branches radiating to the periphery

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9
Q

Histology of FNH?

A

Sinusoids, bile ductules and Kupffer cells are all present; they contain all the liver ultrastructure (they are isotense on sulfur colloid scan)

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10
Q

How common is FNH and what are the symptoms?

A

More common in young and middle-aged women; there is no relation to sex hormones

Usually asymptomatic but can cause minimal pain; there is minimal bleeding risk

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11
Q

Diagnosis of FNH?

A

Ultrasound shows a nodule with varying echogenecity

CT scan shows a hypervascular mass with a central scar

MRI scan shows iso/hypo intense

FNA shows normal hepatocytes and Kupffer cells with a central core

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12
Q

Treatment of FNH?

A

No treatment necessary, inc. in pregnancy and with hormones

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13
Q

What is a hepatic adenoma?

A

Benign neoplasm composed of normal HEPATOCYTES, with NO portal tract, central veins or bile duct (cold on nuclear sulfur colloid scan)

They usually occur in the right lobe

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14
Q

How common are hepatic adenomas?

A

More common in women and assoc. with contraceptive hormones and androgenic steroids (related to duration of use)

Multiple adenomas (adenomatosis) is rare and usually assoc. with glycogen storage disease

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15
Q

Symptoms of hepatic adenoma?

A

Usually asymptomatic (often an incidental finding) but may have RUQ pain and bleeding (size-related)

Presentation may be with rupture, haemorrhage or malignant transformation (rare)

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16
Q

Diagnosis of hepatic adenomas?

A

Ultrasound will show a filling defect

CT scan shows diffuse arterial enhancement

MRI scan shows hypo/hyper intense lesion

FNA may be needed

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17
Q

Treatment of hepatic adenomas?

A

Stop hormones and observe every 6 months for 2 years; if there is no regression, surgical excision is required

Males requires immediate resection, due to higher risk of malignant transformation

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18
Q

5 types of cystic lesions?

A 
Simple 
Hydatid
Atypical
Polycystic
Pyogenic or amoebic abscess
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19
Q

What is a simple cyst?

A

Collection of liquid lined by an epithelium; there is no biliary tree communication and they tend to be solitary, unilocular cysts

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20
Q

Symptoms of simple cyst?

A 
Usually asymptomatic but symptoms can be related to:
Intracystic haemorrhage 
Infection
Rupture (rare)
Compression
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21
Q

Management of simple cysts?

A

No follow-up necessary but, if there is doubt, image in 3-6 months

If asymptomatic or uncertain diagnosis (complex cystic lesion), consider surgical intervention

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22
Q

What is a hydatid cyst?

A

Cyst caused by Echinococcus granulosus (tapeworm parasite)

23
Q

How common are hydatid cysts?

A

Endemic regions are eastern Europe, central and south America, Middle East and North Africa

24
Q

Presentation of hydatid cyst?

A

May present with disseminated disease or erosion of cysts into adjacent structure and vessels, e.g: IVC

25
Q

Diagnosis of hydatid cyst?

A

Appearance and history

Serological testing for anti-Echinococcus antibodies

26
Q

Management of hydatid cysts?

A

Surgery is most common:
Conservative - open cystectomy or marsupialization (opening and drainage of cyst)
Radical - pericystectomy or lobectomy

Medications used inc. Albendazole (parasitic infection)

Percutaneous drainage

27
Q

Risks of hydatid cyst surgery?

A

Operative morbidity

Anaphylaxis or dissemination of infection

28
Q

What is polycystic liver disease?

A

Embryonic ductal plate malformation of the intrahepatic biliary tree, resulting in numerous cysts throughout the liver parenchyma

29
Q

3 types of polycystic liver disease?

A

Von Meyenburg complexes (VMC) - not germ-line genetically driven

Polycystic liver disease

Autosomal dominant polycystic kidney disease

30
Q

What occurs in VMC?

A

Von Meyenburg complexes (microhamartomas) are benign cystic nodules throughout the liver

There are cystic bile duct malformations, originating from the peripheral biliary tree, and remnants develop into small hepatic cysts (usually remain silent in life)

31
Q

Comparison of polycystic liver disease (PCLD) and autosomal dominant polycystic kidney disease (ADPKD)?

A

PCLD:
Liver function is preserved (renal failure is rare)
Symptoms depend on size of cysts
PCLD gene, part. PRKCSH and SEC63

ADPKD:
Renal failure due to PCLD and non-renal, extra-hepatic features are common
Potential massive hepatomegaly
ADPKD genes, part. PKD1 and PKD2

32
Q

Symptoms of PCLD?

A

Abdominal pain and distension

Atypical symptoms occur due to voluminous cysts causing compression of adjacent tissue/failure of affected organ

33
Q

Management of PCLD?

A

Conservative treatment to halt cyst growth (allowing abdominal decompression and to ameliorate symptoms)

Rarely, invasive procedures are required in advanced PCLD, ADPKD or liver failure:
Defenestration/aspiration
Liver transplantation

Somatostatin analogues have beneficial effects with symptoms relief and liver volume reduction

34
Q

Clinical features of a liver abscess?

A

High fever, abdominal pain and chronic malaise

Leukocytosis

Complex liver lesion

History may inc. abdominal/biliary infection, dental procedures or ERCP

35
Q

Management of liver abscesses?

A

Initially, empirical broad-spectrum antibiotics are used

Aspiration/percutaenous drainage; if no improvement, open drainage or resection

4 weeks of antibiotic therapy and repeated imaging

36
Q

Risk factors for hepatocellular carcinoma?

A 
CIRRHOSIS, due to any cause:
Hep B and C
Alcohol
Aflatoxin
Other
37
Q

Clinical features of HCC?

A

May be assymptomatic
Weight loss, RUQ pain and hard, enlarged RUQ mass

Liver bruit (rare)

Worsening of pre-existing chronic liver disease and acute liver failure

38
Q

Where can HCC metastasis to?

A

Rest of the liver and portal vein

Lymph nodes

Lung

Bone

Brain

39
Q

What is alfa fetoprotein (AFP)?

A

A HCC tumour marker, with values >100ng/ml being highly suggestive of HCC; elevation is seen in most patients

Howeve, this level tends to only be seen in those who are no longer candidates for curative therapy

40
Q

Diagnosis of HCC?

A

Elevated AFP

Ultrasound

Triphasic CT scan can show very early arterial perfusion

MRI

Biopsy

41
Q

Therapeutic pathways for different HCC patients?

A

If the single tumour is small + no evidence of portal hypertension or raised bilirubin, resection

If there are assoc. diseases or 3 nodules

42
Q

When is liver transplantation used?

A

Best treatment as it removes tumour and the liver and recurrence rate is low; this is only done if the tumour is

43
Q

When is resection used?

A

For small tumours with preserved LFTs, no jaundice and no portal hypertension

Recurrence rate is high

44
Q

When is local, radiofrequency ablation used?

A

For non-resectable tumours or for those with advanced liver cirrhosis; this is TEMPORARY measure only

Can be used in conjunction with ethanol injections

45
Q

What is transarterial chemoembolisation (TACE)?

A

Inject of chemotherapy selectively into the hepatic artery, followed by injection of an embolic agent

46
Q

When is TACE used?

A

Only used in patients with early cirrhosis and it has no role in systemic chemotherapy

47
Q

What is Sorafenib?

A

Multi-kinase inhibitor of vascular endothelial gf receptor, platelet-serived growth factor receptor and of Raf

Increases survival, minimally

48
Q

How common is fibrolamellar carcinoma?

A

Presents in young patients (5-35 years) and is unrelated to cirrhosis

49
Q

Diagnosis of fibro-lamellar carcinoma?

A

AFP is normal

CT scan shows a typical, STELLATE SCAR with radial septa showing perisistent enhancement

50
Q

Treatment of fibro-lamellar carcinoma?

A

Surgical resection/transplantation is the standard of care

For patients with an unresectable tumour, TACE

51
Q

Primary cancers that can metastasis to the liver?

A 
Most common site for blood-borne metastases:
Colon
Breast
Lung
Stomach 
Pancreas
Melanoma
52
Q

Diagnosis of secondary liver metastases?

A

Dx imaging or FNA

53
Q

Management of secondary liver metastases?

A

Treatment depends on the primary cancer

Sometimes, resection of chemoembolisation is possible

Clinical (54 decks)

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