FNHTR

Question 1

What causes febrile nonhemolytic transfusion reaction?

Answer 1

Activation of donor WBCs when they come into contact with antibodies in the recipient’s plasma

This interaction triggers the release of cytokines from donor WBCs.

Question 2

What symptoms are caused by the release of cytokines in febrile nonhemolytic transfusion reaction?

Answer 2

Fever and chills

These symptoms occur after a blood transfusion.

Question 3

What is the Coombs test result in febrile nonhemolytic transfusion reaction?

Answer 3

Negative

This is because the process doesn’t involve antibodies against donor RBCs.

Question 4

What does a positive Coombs test indicate?

Answer 4

Presence of antibodies against RBCs

A (+) Coombs test means there are Abs against RBCs.

Question 5

Within what time frame do symptoms like fever and chills typically occur after a blood transfusion in febrile nonhemolytic transfusion reaction?

Answer 5

Within 2 hours

This is a key clinical vignette characteristic.

Question 6

What are the two ways the mechanism of febrile nonhemolytic transfusion reaction can be described?

Answer 6

• Preformed antibodies against donor leukocyte antigens
• Cytokine release from transfused blood

Question 7

What process can be used to mitigate the risk of febrile nonhemolytic transfusion reaction?

Answer 7

Leukoreduction

This process removes or reduces the number of WBCs from blood components before transfusion.

Question 8

Fill in the blank: Febrile nonhemolytic transfusion reaction is caused by activation of donor WBCs when they come into contact with _______.

Answer 8

antibodies in the recipient’s plasma