CML

Question 1

What is the genetic cause of chronic myelogenous leukemia?

Answer 1

t(9;22) translocation (Philadelphia chromosome)

The Philadelphia chromosome is a specific genetic abnormality associated with CML.

Question 2

What type of protein is formed as a result of the translocation in CML?

Answer 2

Fusion protein (bcr/abl tyrosine oncogenic tyrosine kinase)

This fusion protein is responsible for the pathogenesis of CML.

Question 3

Which types of cells are associated with chronic myelogenous leukemia?

Answer 3

Myelocytes, promyelocytes, metamyelocytes

These cell types are commonly seen in the blood smear of CML patients.

Question 4

What is the leukocyte alkaline phosphatase (ALP) level in chronic myelogenous leukemia?

Answer 4

Low

This finding helps differentiate CML from other conditions such as leukemoid reactions.

Question 5

How is the blood smear described in chronic myelogenous leukemia?

Answer 5

Motley mix or soup

This description indicates the presence of various types of myeloid cells.

Question 6

What distinguishes the blood smear of CML from a leukemoid reaction?

Answer 6

CML shows a motley mix of cells, whereas leukemoid reaction shows neutrophilia

This difference is crucial for diagnosis.

Question 7

What is the primary treatment for chronic myelogenous leukemia?

Answer 7

Imatinib

Imatinib specifically targets the bcr/abl tyrosine kinase.