CLL

Question 1

What is chronic lymphocytic leukemia (CLL)?

Answer 1

A type of leukemia that typically affects older adults.

Question 2

What age group is commonly associated with CLL?

Answer 2

Older adults.

Question 3

What is a key laboratory finding in CLL?

Answer 3

For example, WBCs 87,000/µL with 90% lymphocytes.

Question 4

What is the next best step when a patient is suspected to have CLL?

Answer 4

Quantitative immunoglobulin assay.

Question 5

What can the quantitative immunoglobulin assay show in CLL?

Answer 5

Monoclonal immunoglobulin.

Question 6

What abnormal cells can be seen on a CLL smear?

Answer 6

Smudge cells.

Question 7

What are smudge cells?

Answer 7

Fragile leukemic cells visible on light microscopy.

Question 8

What surface markers are leukemic cells in CLL positive for?

Answer 8

CD5 and CD23.

Question 9

CLL can be associated with what process

Answer 9

warm autoimmune hemolytic anemia

Question 10

What type of antibody is involved in warm autoimmune hemolytic anemia associated with CLL?

Answer 10

IgG against RBCs.