FMS Weeks 6 & 7 Flashcards
Pathology
What are ERBB1 and ERBB2?
EGFR and HER growth factor receptors
What neoplasias are Actinomycin D used for?
choriocarcinoma, Wilm’s tumor, testicular tumors, Kaposi’s sarcoma
What type of tumors are steroid hormones used in?
HR+ tumors
What type of drug is Mechlorethamine?
alkylating agent
What are the 5 big tumor suppressor genes?
P53, RB, APC, PTEN, CDH1
What typ of drug is Bortezomib?
Proteosome inhibitor
What are the 6 hallmarks of cancer?
SERIE A
SUSTAINING proliferative SIGNALING
EVADING growth SUPRESSORS
RESISTING cell DEATH
INDUCING ANGIOGENESIS
ENABLING replicative IMMORTALITY
ACTIVATING INVASION/METASTASIS
What type of drug is danazol?
Androgen agonist
What is the target of Bevacizumab?
VEGF
What type of drug is Lenalidomide?
angiogenesis inhibitor
what is desmoplasia?
firm abundant collagen in many malignant tumors
characteristics of coagulative necrosis
gross architecture is preserved, firm texture, all organs except the brain
What does the tissue in this slide display?

coagulative necrosis
What is the mechanism of fat necrosis?
Leaking digestive enzymes (such as lipases from the pacreas) destroy cells, causing fatty deposits through saponification, calcium deposits, and inflammatory reaction
How do tumors enable replicative immortality?
upregulated telomerase activity
What are the typical toxicities of bleomycins?
skin lesions, hyperpigmentation, dose-limiting pulmonary fibrosis
What is the mechanism of topoisomerase inhibitors?
bind to DNA/topoisomberase II and stabilize dsDNA; results in double stranded breaks
What is type C Niemann-Pick?
lysosomal storage disease; mutations affecting enzyme in cholesterol trafficking
what are renal tubule resorbtion droplets?
reversible accumulations of protein that are absorbed into the cytoplasm of proximal tubular cells; seen in proteinuria conditions
What are the toxicities of lenalidomide?
severe neutropenia, thromboembolism
What type of drug is Trastuzumab?
Monoclonal anitibody
What are the main causes of hemosiderosis?
overload of iron: increased dietary absorbtion, hemolytic anemias, repeated blood transfusions
What is the mechanism of antineoplastic alkaloids?
disaggregate mitotic spindles (metaphase arrest)
What type of drug is Paclitaxel?
taxane


