Fluid Balance Flashcards
Complications HyperNa
- hemorrhage due to shrinking of brain and shearing of essels
- central pontine myelinosis
Most common causes hyperna due to water gain
- iatrogenic
- improper mixing of forumula
- hyperaldo
Presentation Hyperaldo
hypernatremia with hypokalemia and hypertension
Common cuase hyperna due to water loss
- diabetes insipidus
- intake defciency
What is factitious hyponatremia? Dilutional?
- triglycerides
2. glucose
Causes hyperna due to water loss > na loss
- crhonic renal disuse
- obstructive uropathy
- osmotic diuresis
- skin or GI losses
What is the most common cause of hypovolemic hyponatremia
AGE
Causes hypovalemic hyponatremia
- GI, skin, third spacing, kidney
- diuretics
- cerebral salt wasting
- hypoaldosteronism
pathophys of hypervolemic hyponatremia
increased in ADH due to decrease in effective blood volume (cardiac, third spacing) resulting in water retention
-also increase in Na retention due to RAAS
Causes hypervolemic hyponatremia
- CHF, cirhrhosis, nephrotic
- renal failure
Causes Euvolemic hyponatremia
- SIADH
- water intoxication if kidneys cant eliminate
- glucocorticoid deficiency
- hypothyroidism
Lab Findings SIADH
serum Na < 135
serum osm < 280
Urine Na > 25 (dumps Na due to slight increase in ECF)
Urine osmol > 100
What causes normal anion gap metabolic acidosis?
- diarrhea
- RTA
What causes anion gap metabolic acidosis?
- ketoacidosis
- lactic acidosis
- renal failure (photphate, urate, sulfate)
- drugs: salicylates, ethylene glycol,metahnol, toluene
Best test to determine causes of meatbolic alkalsois?
low or high urinary chloride (low is < 15, high is greater than 20)
Causes chloride responsive (low chloride urine) metabolic alkalosis?
- gastric losses
- chloride losing diarrhea
- thirazides
- loops
- cystic fibrosis
Pathophys chloride responsive metabolic alkalosis?
- volume depletion causes increased resportion of Na and HCO3 in proximal tubule
- increase in aldosterone due to volume depletion causes increase in HCO3 and H+ absorption in collecting ducts; hypokalemia
How do you separate the two types of chloride unresponive (high urine chloride) metabolic alkalosis?
elevated blood pressure or not
High BP chloride resistance metabolic alkalosis
- adrenal hyperplasia or adenomas
- cushing
Normal BP chloride resistance metabolic alkalosis?
- renovascular
- bartter / gittelmann
- AD hypoparathyroidsm
- iatrogenics
What causes metabolic alkalosis in CF?
-loss of NaCl in sweat with dehydration causing metabolic alkalosis with hypokalemia; also hyponatremia
What is Bartter / Gitelman Syndrome
-defect in NaCl in loop of henle -> dehydration –> secondary hyperaldo–>hypokalemic metabolic alkalosis