Collagen Vascular Flashcards
Criteria for Juvenile Rheumatoid Arthritis
- onset at less than 16 years
- arthritis in at least one joint
- symptoms at least 6 weeks
- paicuarticular, polyarticular or systemic disease in first 6 months
- exclusion of other disease
Pauciartciular JRA
- less than 4 joints of the lower extremities; no hip
- positive ANA, chronic anterior uveitis
Polyarticular JRA
- 5+ joints
- usually hand and wrist involvement
- rheum nodules
- cervical and hip
Systemic JRA
- daily spiking fevers
- salmon polymorphous rash
- serosistis
- will have pauci or polyarticular disease
- may have negative sserology
Best Screening Test SLE
ANA
Most specific SLE test
Anti-smith
How to measure disease activity in SLE
anti-ds-DNA
Marker for lupus cerebritis
anti-ribsomal P
Antibodies found in neonatal SLE
anti-ro SSA or anti-La SSB due to maternal IgG crossing placenta
What is a lupus anticoagulant reflective of? What may it give a false positive for?
- assd wtih APL antibodies and DVT
- false positive for syphilis
- can icnrease PTT
Complement SLE
-decreased CH50, C3, and C4
What finding in neonatal SLE typically doesnt resolve?
heart block (prologned PR to third degree)
Presentation Junveile Ankylosing Spondylitis
- males
- arhtitis usually in leg joints plus enthesitis (tendons, ligaments, fascia)
- lateral skeletal joint like sacroiliac
- anteriori uveitis, aortic regurge, atlanto axial subluxation
Labs Juvenile ankylosing spony
- negative ANA and RF
- positive HLA B27
Positive ANA with speckled pattern means…
dermatomyositis (female, age 7)
ESR in Dermatomyositis
normal
Tests Scleroderma
- positive antiScl plus anticentromere antibodies
- ANA wit speckled pattern
Non casesating granulomas in lungs
sarcoid
Kawasakis when do you switch to low dose aspirin
afebrile for 3 days
When should ESR/CRP normalize in kawasakis
2 months
Epidemiology HSP
- follows URI
- age 2 to 8
- males more
Presentation HSP
- low grade fever with arthalgia (serous, knees / ankles)
- buttocks and legs (back of arms too) with pink maculopapules that blanch then ddevelop into petechia/ palpable purpura that resolve in1 to 4 weeks
- colicky abdominal pain
Complications HSP
- intussusception
- renal vasculaitis
Tx HSP
- if any GI involvement give corticosteroids
- renal like GN
- -rember get UA and stool occult on all these patients
