FIP Flashcards
What are the two pathotypes of feline coronavirus?
(Feline enteric coronavirus and feline infectious peritonitis virus)
(T/F) Feline infectious peritonitis virus is not shed or shed at very low levels in the feces of infected cats.
(T, this is why it is considered noncontagious)
What two cell types does feline infectious peritonitis virus infect (and cause subsequent viremia)?
(Monocytes and macrophages)
The humoral response/cellular immunity (choose) is exaggerated in feline infectious peritonitis virus infections.
(Humoral response is exaggerated → hyperactivation of macrophages, intense neutrophil recruitment, overproduction of proinflammatory cytokines)
What results from the suppressed cellular immunity associated with FIP infections that can be indicated by routine blood work?
(Lymphopenia, also suppresses NK cells and there is a lack of certain T cell activation and regulation factors (IL-10, IL-12))
FIP effusions are high/low (choose) in protein and high/low (choose) in cellularity.
(High protein, low cellularity)
Which form of FIP is more severe and more common?
(Wet form)
What blood work changes are more common in the effusive form of FIP?
(Hyperbilirubinemia and lymphopenia; dry can have lymphopenia but it is less common)
What organs are most commonly affected with granulomatous parenchymal lesions in the dry form of FIP?
(Eye and CNS, others are ileocolic junction, ileocecocolic ln, mesenteric lnn, and kidneys)
Do cats with wet or dry (choose) FIP have some, although weak, active cellular immunity?
(Dry)
Which two breeds of cat are overrepresented associated with the dry form of FIP?
(Burmese and Birmans)
What is the gold standard for diagnosis of FIP?
(Biopsies with histopath and IHC; cannot commonly be performed premortem)
Describe the CBC of a cat with FIP.
(Regenerative or non-regenerative microcytic anemia, band neutrophilia, lymphopenia (esp with wet form), and thrombocytopenia)
(T/F) If you are presented with a cat that you suspect has FIP based on there being abdominal effusion but they do not have lymphopenia, you can move FIP very low on your ddx list.
(T)
What is the most common serum chem change noted with FIP infections?
(Hyperglobulinemia)
Describe the fluid analysis results of a FIP effusion.
(High protein count with a low A:G ratio, moderately low cell count, neutrophils and macrophages are the predominant cell types)
What is the purpose of the rivalta test?
(To rule out FIP)
Why are antibody tests not good for diagnosing and even ruling out FIP?
(FIP antibody tests test for FCoV which lots of cats have without signs of FIP, so a positive anti-FCoV Ab does not equal FIP, also not good for ruling out because a negative anti-FCoV Ab does not mean the cat cannot have FIP)
Is an RT-PCR (performed on effusion, FNAs, CSF, and/or aqueous humor) meant to rule in or out (choose) FIP?
(Rule in, it has excellent specificity so you can trust a positive, only good sensitivity so a negative doesn’t necessarily guarantee the animal does not have FIP)
Has immunosuppression (corticosteroids, cytokine inhibitors, interferon, etc.) or immunostimulation for treatment of FIP found to be effective?
(No, neither has found to be effective besides anecdotal cases)
What does the nucleoside analogue GS-441524 do to treat FIP?
(Strongly inhibits FIP viral replication)
(T/F) As of today there are no commercially available, effective therapies for FIP.
(T, nucleoside analogues are not approved by the FDA and your recommending/prescribing of them is illegal (so do it under the table for a little thrill))
