Finding Disease Genes

Question 1

What looks for causal genes directly based on your own hypothesis (hypothesis driven), and is almost always wrong?

Answer 1

candidate gene association studies

Question 2

What are genome-wide association studies?

Answer 2

testing hundreds of thousands/millions of markers (SNPs) across entire genome for correlations in diseased patients

Question 4

What is are candidate gene association studies?

Answer 4

look for causal genes directly based on your own hypothesis (hypothesis driven)- almost always wrong

Question 4

_______ are good for the discovery of genes involved in susceptibility to common complex diseases such as diabetes, asthma, and CAD.

Answer 4

Genome-wide association studies

Question 5

What is a genetic linkage analysis?

Answer 5

search genome for segments disproportionately co-inherited along with disease- non-hypothesis driven

Question 6

Genome-wide association studies are good for the discovery of genes involved in susceptibility to common ______ diseases such as _____.

Answer 6

complex; diabetes, asthma, CAD

Question 7

Genetic linkage analysis is good for ________ but not good for ______.

Answer 7

Mendelian disorders; complex traits

Question 8

What studies a gene directly based on your own hypothesis (hypothesis driven)?

Answer 8

candidate gene DNA sequencing

Question 9

What searches the genome for segments disproportionately co-inherited along with disease (non-hypothesis driven)?

Answer 9

a genetic linkage analysis

Question 10

What is candidate gene DNA sequencing?

Answer 10

study the gene directly based on your own hypothesis (hypothesis driven)