Finalsss Flashcards

1
Q

Refers to the class of organic compounds that contain benzene-like, six-membered rings with 3 double bonds.

A

AROMATIC

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2
Q

Benzene Molecular Formula

A

C6H6

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3
Q

Properties of Aromatic

A

Cyclic-Benzene-like, six-membered rings

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4
Q

electron poor, has a positive charge and electron lovers

A

ELECTROPHILE

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5
Q

electron rich, has a negative charge

A

NUCELOPHILE

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6
Q

Compounds containing halogen bonded to a
saturated sp3-hybridized carbon atom

A

ALKYL HALIDES

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7
Q

Synthesis of alkyl halides from alcohols

A

Preparation of Alkyl Halides

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8
Q

Formation and protonation of Grignard reagents

A

Reactions of Alkyl halides

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9
Q

Alkyl halides react with Magnesium metal in ether
solvent to yield organomagnesium halides.

A

Grignard Reagents

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10
Q

The entering nucleophile attacks the substrate from a
direction 180º away from the leaving group, resulting in an
umbrella-like inversion of configuration at the C atom.

A

Nucleophilic Substitution Reaction
o SN2 reaction

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11
Q

 Base abstracts a proton at the same time that the
leaving group departs.

A

Eliminations
o E2 reaction

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12
Q

the substrates spontaneously dissociates to form a
carbocation, which can subsequently lose H+
from a neighboring carbon

A

Eliminations
o E1 reaction

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13
Q

: far higher than alkyl halide and alkanes with the same molecular wt.

A

BP of alcohols

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14
Q

far higher than other aromatic hydrocarbons
o = Because of hydrogen bonding

A

BP of phenols:

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15
Q

Reduction of Aldehydes to Give

A

Primary Alcohol

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16
Q

Reduction of Ketones to Give

A

Secondary Alcohol

17
Q

Reduction of Esters to Give

A

Primary Alcohol

18
Q

Reduction of Carboxylic Acids to Give

A

Primary Alcohol

19
Q

Dehydration to Give

20
Q

Oxidation to Give

A

Carbonyl Compounds

21
Q

Synthesis of Ethers

A

o Wiliamson Ether Synthesis
o Epoxides

22
Q

Reaction of ethers

A

o Acidic cleavage with HBr or HI
o Epoxides cleavage with aqueous acids

23
Q

Production of carbonyls

A

 Alcohols > Aldehydes > Carboxylic acids
 Alcohols > Ketones

24
Q

Common oxidizing reagent

A
  • PCC
  • CrO3, Na2Cr2O7
25
PCC
Alcohol to aldehyde
26
CrO3, Na2Cr2O7:
Alcohol to carboxylic acid or Ketone
27
One of the most important reaction in biochemical reaction
Quinone-hydroquinone interconversion
28
Alcohol-like reactions of phenols (Ether synthesis)
Reactions of Phenols
29
same reaction mechanism but dehydration/RX formation with HX (Not possible)
Ether formation
30
o In most cases, ethers are pretty stable o But return to alcohol by strong mineral acid (HI and HBr)
Reactions of Ethers
31
 as cyclic ether but much more reactive  (oxirane) is three membered oxygen heterocycle  Synthesis: Alkene/Aromatics with Peroxyacid
Epoxides
32
Analogues of alcohol with –SH rather than –OH
Thiols
33
Reducing reagent
- NaBH4 - LiAlH4
34
Reducing catalyst
H+ / H3O+
35
Primary alcohol weak oxidizing reagent
Aldehyde
36
Primary alcohol strong oxidizing reagent
Carboxylic acid
37
Secondary alcohol strong oxidizing reagent
Ketone group
38
Weak oxidizing reagent
PCC: Alcohol to aldehyde
39
Strong oxidizing reagent
Cr3,Na2Cr2O7: Alcohol to Carboxylic Acid or Ketone