Final: Old Exams Review Questions Flashcards
1
Q
GI absorption
A
unionized
2
Q
Weak acid
A
best absorbed at low pH
Trapped, ionized, and excreted at high pH
3
Q
Weak base
A
best absorbed at high pH
Trapped, ionized, and excreted at low pH
4
Q
phase 1
A
catabolic, subtractions
cyto p450
5
Q
phase 2
A
conjugation, anabolic, build up (UDP stuff)
6
Q
affinity
A
does it bind
7
Q
efficacy
A
what does it do
8
Q
Does response curve
A
POTENCY
effect in population
9
Q
Kd
A
saturation curve (50% receptor)
drug affinity for specific receptor
k2/k1
10
Q
increase potency ___ ED50
A
decrease
11
Q
increase efficacy ___ Bmax
A
increase B max (number of receptors)
12
Q
potency
A
accessibility, affinity, intrinsic activity
13
Q
Ki
A
competition, displace 50% ligand
14
Q
increase affinity
A
decrease Kd/Ki
15
Q
Love the craving more than the high
A
incentive sensitization
