final lecture 6

Question 1

vitamin D helps

Answer 1

maximize intestinal Ca absorption

Question 2

dihydrotachysterol (DHT)

Answer 2

is a synthetic vitamin D analog used in pts w/ kidney failure bc dose not require 1alpha-hydroxylation!

Question 3

1st generation bisphosphonates

Answer 3

reduce resorption by increasing osteoclast cell death & inhibiting its function

Question 4

2nd/3rd gen bisphosphonates

Answer 4

nitrogen containing; interfere w/ isoprenoid lipid biosynthesis

Question 5

bisphosphonates must be taken

Answer 5

on an empty stomach

Question 6

inadequate prenylation leads to

Answer 6

compromised osteoclast function & apoptosis (N bisphosphonates)

Question 7

teriparatide

Answer 7

recombinant PTH
only anabolic (bone growing) agent

Question 8

max period of use of teriparatide

Answer 8

2 years

Question 9

calcitonin

Answer 9

reduction in ruffled border surface of osteoclasts-> diminished resoptive activity

Question 10

RANKL is expressed by

Answer 10

osteoblast precursors

Question 11

OPG

Answer 11

decoy receptor for the RANKL preventing it from bining RANK on osteoclasts

Question 12

denosmab

Answer 12

fully human mab against RANKL

Question 13

denosumab indication

Answer 13

severe osteoporosis in postmenipausal women

Question 14

raloxifene

Answer 14

estogen agonist in bone but estrogen antagonist in brest & endometrial tissue

Question 15

take Ca with meals to

Answer 15

improve absorption

Question 16

side effects w/ calcium supplemetns

Answer 16

constipation, gas, upset stomach