Final exam Study Flashcards
phenol
chemical disinfectant
injure lipids of plasma membrane causing leakage
remain active in presence of organic matter
what did joseph lister do
used phenol to control surgical infections in the operating room
phenolic
chemical disinfectant
derivative of phenol
reduce irritation
increase effectiveness
O phenylphenol and ingredient in Lysol
biphenol
chemical disinfectant
two phenol groups connected by a bridge
disrupt plasma membranes
chlorohexidine
Biguanide - used in surgical hand scrubs, preoperative skin preparations
Alexidine
Biguanide - works faster than chlorhexidine
Essential Oils
mixtures of hydrocarbons extracted from plants - used for centuries in traditional medicine and preserving food
Microbial uses of Essential Oils
action comes primarily due to phenolics and terpenes -stronger activity against gram pos bacteria, effectiveness against viruses not studied to date
Tea tree oil and pine oil
Broad spectrum of activity that includes gram pos and gram neg and fungi
Iodine
Halogen - impairs protein synthesis and alters membranes - water treatment
Tincture
Iodine (halogen) - solution in aqueous alcohol
Iodophor
Iodine (halogen) - combined with organic molecules - povidone iodine: skin antisepsis
Chlorine
Halogen - oxidizing agent, shut down cellular enzyme systems - municipal water disinfection
Bleach
Chlorine (halogen) Hypochlorous acid ( H O Cl)
Chloramine
Chlorine (halogen) Chlorine + Ammonia
Alcohols
- Denature proteins and dissolve lipids - no effect on endospores and nonenveloped viruses
Ethanol and isopropanol
Alcohols that require water
Alcohol based hand sanitizer
- about 62% alcohol - effective against most bacteria
Alcohol based hand sanitizers are not effective against…
not against endospore producers and nonenveloped viruses - examples: Clostridium difficile, norovirus
Oligodynamic action
When very small amounts (of metal) exert antimicrobial activity
How are metals antimicrobial
Denature proteins
Silver nitrate
Prevent ophthalmia neonatorum
Silver
Impregnated wound dressings
Mercuric chloride
Limited use as disinfectant TOXIC
Copper sulfate
Algicide (used in pools)
Cu2+ and Ag+ ions
Water disinfection
zinc chloride
mouthwash
Acid-anionic sanitizers
Soap - anions react with plasma membrane - used for cleaning food processing facilities
quats are ineffective against
endospores
mycobacteria
Quaternary ammonium compounds (quats)
Soap - cations are bactericidal, denature proteins, disrupt plasma membrane - relatively broad spectrum