Final Exam Nicotine Flashcards

1
Q

Nicotine:

A

the Psychoactive Ingredient in Tobacco

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

tobacco is the dried leaves of __, which grows in North and South America

A

nicotiana tobacum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

tobacco leaves are dried and processed into forms that can be (3)

A

smoked (cigarettes, pipes, cigars)
chewed (chew)
snorted (snuff)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

tobacco use can be traced back __ years in both North and South America

A

8,000

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

By __, tobacco was a major US export

A

1630

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

per capita cigarette consumption varies widely across countries, with the US falling in __

A

the middle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

the highest rates of smoking in the US are in the __ and __

A

lower Midwest

South

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The same states with the highest rate of smoking also have some of the ___

A

shortest life expectancies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

although chewing tobacco, cigars, and pipe tobacco once comprised significant categories of use in the US, __ now predominate

A

cigarettes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

tobacco smoke contains (3)

A

nicotine
carbon monoxide (CO)
tar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

tar:

A

is the residual substance left after nicotine is removed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tar contains various (3)

A

toxins
carcinogens
tumor-initiating agents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

although cigarette use continues to decline, alternative administration routes __are now common, especially among young people

A

(vaping)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

vapors from e-cigs contain far fewer carcinogens, but can yield more __

A

sustained, higher nicotine blood plasma levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Societal Costs of Tobacco Use
__% of all people ages 12 and older have engaged in tobacco use
__% have engaged in cigarette use
__ million people are cigarette dependent at any given time (point prevalence)
__ billion in tobacco-related medical costs are incurred each year

A

67.5
62.8
22.9
$170

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

True or false? smoking is the leading cause of preventable death

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

___ people (equivalent to almost 1/2 of Columbus) die each year from smoking-related illnesses

A

480,000

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

__ million people are living with a disease caused by smoking

A

16

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

smokers die, on average, over __ years earlier than non-smokers

A

10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

both smoking and second-hand smoke exposure during pregnancy are associated with several adverse outcomes, including (5)

A
low birth weight
childhood ADHD and conduct problems
asthma
SIDS
vulnerability to drug use in adolescence
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

until recently, vaping was considered safer, but in 2019, ___ cases of e-cigarette, or vaping, product use associated lung injury (EVALI) have been reported
__ deaths confirmed
causes are not fully understood, but all patients have vaping histories
__ is present in most but not all samples

A

1,604
34
THC

22
Q

nicotine use induces (6)

nicotine also has mild pain-reducing qualities

A
mild euphoria
increased energy
heightened arousal
reduced stress
anxiolytic effects (reduce anxiety)
reduced appetite
23
Q

anxiolytic effects means

A

reduce anxiety

24
Q

Behavioral Effects of Nicotine (5)

A
improved attention
shortened reaction time
better problem solving
improved cognition
increased heart rate and blood pressure
25
inhaled cigarette and e-cig vapors reach the brain within __
8 seconds
26
True or false? almost all nicotine is delivered through the lungs
true
27
There are large individual differences in blood plasma nicotine observed from the same dose. Those who are addicted maintain ___ throughout the day. Different tobacco preparations yield ___
high blood levels of nicotine | different blood concentration curves
28
Prevalence of smoking rises sharply from ages ___ to ___ | Rates fall slowly across adulthood
12 (2%) to 17 (28%)
29
About __% of adolescents who try smoking become daily smokers within 4-5 years
50
30
Those who smoke __ cigarettes per day for at least __ years NEVER return to light smoking
15 or more | 2
31
Nicotine abstinence syndrome refers to
withdrawal effects after prolonged use
32
There are 2 types of symptoms of nicotine abstinence syndrome what are they?
somatic and affective symptoms
33
somatic symptoms (4):
bradycardia (slowed heart rate) gastrointestinal discomfort increased appetite weight gain
34
affective symptoms (5):
``` depression irritability dysphoria anxiety difficulty concentrating ```
35
Many of these symptoms of nicotine abstinence syndrome result from ___ in the mesolimbic DA system
dopamine depletion
36
Koob et al. (2014) state that acute withdrawal lasts up to __ days, but longer timeframes are reported by heavy smokers—especially __
30 | women
37
As with other DA agonists, cravings can last up to __
6 months
38
Nicotine replacement therapy is only about __% effective at one year
25
39
___, an NDRI antidepressant, can be up to __% effective; it increases midbrain DA levels and blocks the psychoactive effects of stimulants, including nicotine
bupropion (Wellbutrin) | 50
40
Bupropion (Wellbutrin), an NDRI antidepressant, can be up to 50% effective; it increases __ DA levels and blocks the __ of stimulants, including nicotine
midbrain | psychoactive effects
41
Neurobiological Effects: Nicotine is a ____
nicotinic acetylcholine receptor (nAChR) agonist
42
nAChR (nicotinic acetylcholine receptor agonist) families are expressed throughout the brain and body (3)
muscles: α1, β1, ϒ, δ, ε central nervous system: α2-α6, β2-β4 β2 especially important for reinforcing effects
43
In nAChR expression, __ is especially important for reinforcing effects
β2
44
neuronal nAChRs activate other neurons by opening __ and through other mechanisms
calcium ion channels
45
animals will self-administer nicotine, but their break point is much __ than for __
lower | cocaine
46
nicotine has analgesic (pain-reducing) effects, likely through activation of __ and __receptor subunits, which increase __ in the NAcc
α4β2 α7 nAChR opioid peptide levels
47
at low doses, nicotine facilitates __ in rats; and at high doses, it __
social behavior | dampens such behavior
48
Nicotine's acute reinforcing effects occur through __ in the __ (VTA, NAcc) via the β2 subunit
dopamine release | mesolimbic DA system
49
Nicotine's acute reinforcing effects occur through dopamine release in the mesolimbic DA system (VTA, NAcc) via the __
β2 subunit
50
The VTA (Ventral Tegmental Area) has nAChRs on __ cell bodies and dendrites of __
both | DA neurons
51
β2 knockout mice will __
not self-administer nicotine
52
Nicotine administration raises __ (α7) and reduces __ (α4β2) in the VTA, which increases __
glutamate levels GABA levels DA release