Final Exam in class questions

Question 1

C omplete the following sentence. “ the mitogen activated protein (MAP) kinases…”
A. are intracellular signaling enzymes that respond to extracellular information and mediate cellular response.
B. are extracellular signaling enzymes that respond to intracellular information and mediate cellular responses.
C. bind to the extracellular domain of receptor tyrosine kinases.
D. add acetyl groups to substrates.
E. add glycosyl groups to substrates.

Answer 1

A

Question 2

Ras is a G-protein that is often mutated and constitutively active in cancer cells. which of the following is true about Ras proteins?
A. Ras is activated by FTPase activating Proteins (GAPs)
B. Ras is activated by guanine nucleotide exchange factors (GEFs).
C. GDP bound Ras activates downstream protein kinases.
D. Ras proteins have no post translational modifications.
E. All of the above are true.

Answer 2

E

Question 3

Which caspase initiates the intrinsic apoptotic pathway.
A. Caspase 8
B. Caspase 9
C. Caspase 3
D. Caspase 6
E. All of the above

Answer 3

B

Question 4

Which of the following protein binding domains would be directly affected by a drug that inhibited the EGFR receptor tyrosine kinase?
A. SH3 domain
B. SH2 domain
C. PH domain
D. all of the above 
E. None of the above

Answer 4

B

Question 5

Ruxolitnob (Jakafi) and Tofacitnib (Xeljanz) are ATP- competitive JAK1/2 inhibitors used to treat blood disorders and inflammation. which of the following Jak/ STAT signaling events are affected by these inhibitors?
A. autophosphoroylation of JAK proteins.
B.Phosphorylation of STAT proteins.
C. STAT protein dimerization
D. STAT translocation to the nucleus 
E. all of the above

Answer 5

E