Final Exam

Question 1

What are the 4 cell types in gastric pits and what do they each secrete?

Answer 1

• Mucus neck cells: secrete mucus
• Chief cells: produce pepsinogen
• Parietal cells: Make HCl and intrinsic factor (necessary for Vit B12 absorption
• Endocrine cells: produce gastrin

Question 2

What are the three components to the gastric mucosal barrier?

Answer 2

• Apical cell membrane and tight intracellular junctions relatively impermeable to abide
• Mucus layer
• High local bicarbonate concentrations secreted by surface epithelial cells