Final Flashcards
What kind of testing is an ESR?
Screening
The ESR is directly proportional to what?
Red blood cell mass
What factors affect the ESR?
Red blood cells, plasma, mechanical/technical
Larger and smaller cells affect the ESR how?
Larger cells fall faster smaller cells and settle more quickly
What dyes are used for a wright stain?
Eosin and methylene
How many slides do you look at for a reticulocyte test?
2
How do you determine the absolute retic count?
Retic percent in decimal form times red blood cell count
What can cause decreased reticulocyte count?
Aplastic anemia
exposure to radiation
chronic infection
certain medications
What can cause an increased reticulocyte count?
Rapid blood loss high elevation hemolytic anemia certain medications pregnancy
What is the difference between a manual white blood cell count in a manual platelet count?
Average # /(.01x.1x9) for wbc
Average # /(.01x.1x9) for platelets
What are the quantitative test for platelets?
Platelet count
peripheral smear
What does in vivo mean?
Measurement of platelet function when vascular some endothelium is injured
What is a clot retraction test?
What is allowed to clock in glass tube. Degree of clot retraction is limited by fiber and contractions of the hematocrit. Degree of retraction is directly proportional to the number of platelets and inversely proportional to the hematocrit and amount of fibrinogen
Platelet adhesion test does what?
Runs blood through a column of glass platelets are checked before and after to see difference
How does a platelet aggregation test done
Platelet rich plasma treated with known aggregating agent is measured with light. As the plasma becomes more turbine less light comes through
Platelet factor three and platelet factor four are what?
Antiplatelet antibodies
What does aspirin do to clotting?
It prevents the adding of coming clooxygenase 1
What does thromboxaneA2 do?
It stimulates the activation of new platelets as well as assist with aggregation
What is primary hemostasis?
Blood vessel response (vasoconstriction) platelet response (forming a platelet plug)
What is the difference between serum and plasma?
Serum is the fluid component that does not play a role in clotting. Plasma is everything else
What does the Buffy coat contain?
White blood cells and platelets
What are the platelet granules?
Alpha, Delta, lysosomes
What is the Alpha granule responsible for?
They are the most abundant they are secreted not released participate and adhesion, aggravation, plasma Coag
What are delta granules responsible for?
Serotonin: vasoconstrictor
ADP: activate platelet a TP: energy calcium: secondary coagulation released not secreted
