Chapter 1 - Hematopoesis

Question 1

What is hematopoiesis?

Answer 1

Production, development, differentiation, and maturation of all blood cells.

Question 2

During development where does hematopoiesis take place?

Answer 2

In RE5 organs (yolk sac, liver, and spleen)

Question 3

In adults where does hematopoiesis take place?

Answer 3

Skull, clavicle, sternum, ribs, vertebrae, pelvis, and proximal ends of long bones.

Question 4

What is the difference between intramedullary hematopoiesis and extramedullary hematopoiesis?

Answer 4

Intramedullary hematopoiesis is within the bone marrow.
Extra medullary hematopoiesis is outside of the bone marrow (primarily liver and spleen
-Usually due to abnormal demand for blood or bone marrow failure causes and enlargement in the liver and spleen called hepatosplenomegaly

Question 5

What is the reticuloendothelial system?

Answer 5

AKA: mono nuclear phagocytosis system
Responsible for the production release and elimination of blood cells
-murder:Phagocytosis
-suicide=Apopptosis
Includes spleen, liver, timers, lymph nodes, and bone marrow.

Question 6

What do multi potential stem cells differentiate into?

Answer 6

Non-lymphoid or lymphoid precursor committed cells

Question 7

What do you non-lymphoid committed cells develop into?

Answer 7

The entire white cell line, red cells, or megakaryocytic family.

Question 8

What do Lymphocytic committed cells develop into?

Answer 8

T cells or B cells

Question 9

Which white blood cells are granulocytes?

Answer 9

Neutrophils, eosinophils, basophils.

Question 10

True or false and healthy peripheral blood you will see immature cells

Answer 10

False bitch

Question 11

True or false blood cells progressed through a gradual maturation process?

Answer 11

True bitch

Question 12

What are three ways that sells change as they mature?

Answer 12

Size, cytoplasmic changes, nuclear changes.

Question 13

Are immature cells larger or smaller than mature cells in most cell lines?

Answer 13

Larger

Question 14

What are the cytoplasmic changes do you look for in a maturing cell?

Answer 14

N/C ratio: Ratio of amount of nuclear material to the amount of cytoplasm
Color: deep blue is more RNA lighter blue is RNA loss
Granules: Few non-specific (primary)
many specific (secondary)

Question 15

Blood cells have no color under the microscope. What causes there to be color?

Answer 15

Wrights stain
Eosin (acid) red
Methylene blue (basic) blue

Question 16

Neutral components of the cell take up both dyes and result in what color?

Answer 16

Lavender and pink

Question 17

A high N/C ratio is a characteristic of an immature cell?

Answer 17

True

Question 18

The cytoplasm and immature cells is dark blue color due to high amounts of DNA?

Answer 18

False It’s due to high amounts of RNA

Question 19

True or false the nuclear chromatin pattern in mature cells is course, condensed, and clumpy?

Answer 19

True

Question 20

True or false nucleoli are visible in the nucleus of mature cells?

Answer 20

Mostly false, usually only an immature cells lymphs being the exception