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Hemotology > Chapter 4 - Granulocytic series > Flashcards

Chapter 4 - Granulocytic series Flashcards

1
Q

What is Leukopoiesis?

A

Production of white blood cells.

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2
Q

What are the three main categories of mature white blood cells

A

Granulocytes neutrophils eosinophils basophils
monocytes
lymphocytes plasma cells

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3
Q

What do granules contain?

A

Enzymes that digest and destroy invading organisms

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4
Q

What is the neutrophil maturation sequence?

A 
Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band
Segmented neutrophil
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5
Q

What are some characteristics of a myeloblast?

A

14 to 20 µm
2 to 5 nucleoli
no granules
All three granulocytes originate from this

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6
Q

What are some characteristics of a promyelocyte?

A

15 to 20 µm
nucleus is oval/round
primary granules appear

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7
Q

Myelocyte Characteristics?

A 
10 to 18 µm 
nucleus is oval but slightly indented 
at this stage due to granule formation the cell can be Differentiated 
last stage capable of mitosis 
production of primary granules stops
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8
Q

What are some characteristics of a metamyelocyte?

A

10 to 15 µm
no nucleolus present
indentation does not exceed 1/2 the width of the nucleus
not capable of mitosis

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9
Q

What are some characteristics of a band?

A

9 to 15 µm

horse shoe shaped

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10
Q

What are some characteristics of a segmented neutrophil?

A

9 to 15 µm ID is based on chromatin

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11
Q

Eosinophil maturation?

A 
Myeloblast
Promyelocyte
Eosinophilic  myelocyte
Eosinophilic metamyelocyte
Eosinophilic band 
Eosinophil
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12
Q

Characteristics of an Eosinophil?

A

10 to 16 µm
bilobed
granules contain histamine
Increase in allergic reactions

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13
Q

Stages in basophilic maturation

A 
Myeloblast
promyelocyte 
basophilic Myelocyte
basophilic metamyelocyte 
basophilic band 
basophils
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14
Q

Basophils characteristics?

A

10 to 14 µm
N:C ratio difficult to determine
large purple blue and black granules
play a role in allergic reactions and inflammation granules contain histamine and heparin

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15
Q

The compartments of bone marrow storage?

A

Miotic pool
maturation storage pool
marginating pool
circulating pool

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16
Q

Mitotic pool contains what?

A

Myeloblast, promyelocyte, myelocyte

17
Q

What does the maturation storage pool hold?

A 
Cells that are maturing and will be let into peripheral blood when needed 
Myeloblast 
promyelocyte
myelocyte 
metamyelocyte 
band 
segmented neutrophil
18
Q

What is the marginating pool?

A

White blood cells located along the vessel endothelium
ready to migrate to site of injury or infection
represent 50% of the cells in peripheral blood
bands
segmented neutrophils

19
Q

What is the circulating pool?

A

White cells in the peripheral blood

Hemotology (9 decks)

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