Chapter what the fuck ever Flashcards by Mitch Novak

Q

What does electrical impedance check?

A

Cell size/count

electrical resistance through aperture size means identified

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Optical scatter facts?

A

Laminar, single file line
counts,size,structure, shape, reflectivity,
different light angles measure volume, internal complexity, and components

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What does the beckman coulter use to measure?

A

(VCS) Volume, conductivity, scanner

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Beckman coulter uses what?

A

Volume, conductivity, scatter

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Sysmex machine uses what?

A

Electrical impedance, Hydro Namic focusing, fluorescent flow and light scatter

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What do the relative and absolute values represent?

A

Relative represents percent absolute represents actual number of cells

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What does a histogram show?

A

Size on the X axis number on the Y axis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What features identify a cell?

A

Size, nucleus chromatin pattern, cytoplasm size of the granules

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the causes/identifiers of reactive lymphocytes?

A

Dark blue outer edge mono, CMV, hepatitis (viruses)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What do plasma cells make?

A

Immunoglobulins

Lg(GAME)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Giant platelets can be caused by what? What do they do to testing?

A

They can be induced by pseudo thrombocytopenia

They can cause pseudo leukocytosis falsely raising white blood cell count

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Causes of white blood cell inclusions?

A

Infection, inflammation, chronic disease, parasitic infection

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are and leukoerythroblastic reactions?

A

Increase in bands in metamyelocytes
Luekomoidis exaggerated response
Leukoerythroblastic is immature white blood cells red blood cells and platelets causing myleofibrosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What does full cytometry measure? How does it measure?

A

Measures quantity, size, morphology, internal/external cell structure
Fluorescent signals admitted to specific antibodies uses cluster of differential for cell and cell lineage

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

An increase in white blood cells is called what?

A

Leukocytosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause a rise in Neutrophils?

A

Bacterial infections, stress, drugs

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause eosinophilia?

A

Parasitic infections, asthma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause basophilia?

A

Anaphylaxis, hyperlipidemia, hypersensitivity

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause lymphocytosis?

A

Viral infections

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause monocytosis?

A

Chronic infections

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is a decrease in white blood cells called?

A

Leukocytopenia

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause neutropenia

A

Chemotherapy

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What would cause basopenia?

A

Steroid, inflammation, ovulation

Q

What would cause eosinopenia?

A

Acute infections

What would cause lymphopenia?

Chemotherapy, HIV because it kills T cells

What would cause monocytopenia?

Steroid therapy, hemodialysis, sepsis

What are some Qualitative changes in white blood cells?

Toxic granulation, toxic vascularization, dull bodies

What are some causes of toxic granulation?

Intense granules in Meadows, bands, and sags

What is toxic vascularization?

Vacuoles in neutrophil Reflects phagocytosis Serious infection can be seen with both other toxic changes

What are dohle bodies?

Remnants of RNA, seen in infections, poisoning, burns, chemotherapy

What are Auer rods made of?

Azurophillc granules | always a significant find

What are two insignificant white blood cell inclusion?

Barr bodies and pyknotic nuclei

What is May Hegglin?

Large platelet but few poor granulation autosomal dominant

What is Aulder Riley?

Autosomal recessive, toxic granulation in all cells not just neutrophils and monocytes

What do Pelger Hewitt inclusions look like? Are they significant?

Bilobed neutrophils they are of no clinical significance

Chediak higashi has what effects?

Autosomal recessive, albinoism, fatal in children, results in recurrence staff infections

What are the stages of a megakaryocyte?

Megakaryoblast, pro megakaryocyte, megakaryocyte

True or false and megakaryoblast the nucleus divides with cytoplasmic division?

False

What are some identifiers of a pro megakaryocyte?

Course chromatin, not capable of endomitosis

What are some characteristics of a megakaryocyte?

Largest cells in bone marrow, shedding of platelets begins

What is thrombopoiesis?

The formation of platelets in bone marrow

Where do megakaryoblast originate from?

My butt hole or pluripotent stem’s

How much platelets are flowing through peripheral blood

80% in blood 20% in spleen

What is the lifespan of a platelet? How long does the maturation take?

Platelets live for 9 to 11 days maturation takes five days

What are the four components of hemostasis?

Vascular system, platelets, coagulation factors, fibrinolysis

What role does the vascular system play in hemostasis?

Contracts using vasoconstriction basement membrane produces collagen

What role does fibrinolysis play?

Your mama or it breaks down clots

What maintains the shape of a platelet?

Microfilaments and tubules

What role does glycogen play?

Glycogen is a protein platelet uses glycolysis to generate energy

What are the coagulation factor pathways?

Extrinsic, intrinsic, common they form a stable blood clot

What are the steps for platelets in hemostasis?

Adhesion, aggravation, release/secretion, clot stabilization, clot retraction

What are the primary steps of hemostasis involving platelets

Adhesion, aggregation, release/secretion

What are the secondary hemostasis roles of clots

Clot stabilization, clot retraction

Alpha granule characteristics?

They are the most abundant they are secreted not released participate and adhesion, aggravation, plasma Coag

What do delta/dense granules contain?

Serotonin: vasoconstrictor | ADP: activate platelet a TP: energy calcium: secondary coagulation released not secreted

What do lysosomes store?

Hydrolase enzymes that digest vessel walls and debris like dead epithelial cells

What is released/secreted in the clotting process?

Delta granules, alpha granules, prostaglandins responsible for coagulation and pain, thromboxane A2