Final Flashcards
Graded vs action potentials?
Graded: short distance/lived, low energy
Action: long distance, high threshold
What is frequency?
More impulses, stronger the stimulus
2 things that affect conduction rate?
axon diameter (larger, faster) and degree of myleination (salatory vs. continuos)
White matter vs grey matter
white matter- myleinated
grey matter- unmyleinated
Three groups of neurons (A, B, C)
A is biggest, C smallest
speed decreases with size
A is most myleinated, C is least
What groups of neurons are in ANS?
Group B and C
What is neuronal pool?
functioning group of neurons, intergrates and forwards info
Draw AP graph, with chemicals going in and out
DRAW
What is a simple neuronal pool?
1 fiber branches into a pool
Discharge zone vs facilitated zone?
Discharge- closer to fiber, more likely to generate impulse
Facilitated- less likely to generate impulse, must be excited by external source
Excitatory postsynaptic potentials (EPSP)
excitatory, depolarization, Na and K
Inhibitory postsynaptic potentials (IPSP)
inhibitory, hyperpolarizes, Cl or K
Indirect vs direct transmission?
Indirect- neurotransmitters w/ G proteins
Direct- ion binds to channel, faster, shorter
How are post synaptic potentials different from APs?
Short distance, chemical channels (not voltage), voltage dependant, no refractory period, no + feedback, use Na, K, Cl
4 steps of GPCR binding?
1- neurotransmitter binds to GPCR
2- GDP released, GTP bind to g protein w/ adenylate cyclase
3- AC converts ATP to CAMP
4- CAMP opens channels, changes permeability
GABA (gamma-aminobutyric acid)
inhibitory neurotransmitter - opens cl- channels
- controls retina of eye
ACh (acetylcholine)
excitatory or inhibitory depending on tissue
PNS - neuromuscular junction
CNS - cortex, hippocampus, brain stem
Norepinephrine
inhibitory or excitatory
- sympathetic NS
- related to dopamine release
- basal ganglia in the CNS (Parkinson’s disease)
Serotonin
Affects mood, hunger, sleep, and arousal
- hypothalamus has to do with wakefulness
Substance P
A neurotransmitter that is involved in the transmission of pain messages to the brain.
- endorphins block the pain
Nitic Oxide (NO)
excitatory in CNS for memory formation
VGAT (vesicular GABA transporter)
hyperpolarizing / inhibitory