FINAL Flashcards
1
Q
Long - Acting Anti- inflammatory
Cromolyn
A
- Inhaled via nebulizer
- MOA: inhibits mast cell degranulation
- AE: Throat irritation, cough
2
Q
Anti-inflammatory Corticosteroids
- Beclomethasone
- Prednisolone
A
- Inhaled (most common), oral
- MOA: Decrease synthesis of inflammatory mediators
- Used to improve breathing with Pt dealing with asthma
- AE: oropharyngeal candidiasis, dysphonia
- Oral AE: hypokalemia, hyperglycemia, adrenal suppression (prolonged use), Cushing-like syndrome
NI:
- evaluate for thrush with prolonged use
- have pt rinse mouth after use
- monitor for glood glucose
3
Q
Methylxanthines
Theophylline
A
- MOA: Dilate bronchial smooth muscle by inhibiting PDE3/4
- AE: Narrow therapeutic window, interacts with everything (caffeine)
- Tachycardia -> convulsions and death
- DDI B2 agonist (excessive tachycardia)
- Monitor HR
- Monitor blood levels (narrow therapeutic window)
4
Q
Short acting B2 Agonist
Albuterol
A
- MOA: Dilate bronchial Smooth muscle
- AE: tachycardia, angina
- monitor HR
5
Q
Long acting B2 Agonist
Salmeterol
A
- MA: Dilate bronchial Smooth muscle
- AE: asthma related death (monotherapy), tachycardia/dysrhythmias, tolerance
6
Q
Muscarinic Antagonist
Short acting: Ipratropium
Long acting: Tiotropium
A
- MAE: bronchodilation by antagonizing muscarinic receptors in the lung
- AE: dry mouth
7
Q
Anti-leukotrienes
- Zafirlukast
- Montelukast
A
- Oral administration
- MAE: suppress inflammatory action of leukotrienes
- AE: risk of depression
8
Q
Biologics
Omalizumab
A
- Injected SubQ
- MA: antagonist of IgE (the allergen immunoglobulin)
- AE: injection-site reactions, increased risk of infection
