Fibrinolysis

Question 1

• Final stage of hemostatic activation
• Fibrin degradation; restoring normal blood flow during vascular repair

Answer 1

Fibrinolysis

Question 2

Systematic, accelerating hydrolysis of fibrin by

Answer 2

Plasmin

Question 3

Inactived form of plasmin present in circulating blood

Answer 3

Plasminogen

Question 4

If plasmin breaks the fibrin polymer (the unstable one), the product is called

Answer 4

FDP or Fibrin Degradation Products (fragments X, Y, D, and E)

Question 5

If plasmin breaks the crosslinked fibrin (the stable one), the product is called

Answer 5

Fragment D-D or D-dimer

Question 6

2 activators of Fibrinolysis

Answer 6

Tissue Plasminogen Activator (TPA) and Urokinase Plasminogen Activator (UPA)

Question 7

Tissue Plasminogen Activator (TPA) is secreted by

Answer 7

Endothelial cells

Question 8

Urokinase Plasminogen Activator (UPA) is secreted by

Answer 8

Urinary tract epithelial cells, monocytes and macrophages

Question 9

The central E domain with the two D domains (D-E-D), minus some peptides cleaved by plasmin

Answer 9

Fragment X

Question 10

The E domain after cleavage of one D domain (D-E)
D-E fragments are further digested to individual D and E domains

Answer 10

Fragment Y

Question 11

Produced by digestion of either fibrin or fibrinogen by plasmin

Answer 11

Fragment X, Y, D, E

Question 12

Composed of two D domains from separate fibrin molecules (not fibrinogen) cross-linked by the action of factor XIIIa

Answer 12

Fragment D-D (D-Dimer)

Question 13

Specific product of digestion of cross-linked fibrin only

Answer 13

Fragment D-D (D-Dimer)

Question 14

Marker of thrombosis and fibrinolysis

Answer 14

Fragment D-D (D-Dimer)

Question 15

Inhibitors of Fibrinolysis

Answer 15

• Plasminogen Activator Inhibitor-1 (PAI-1)
• Α2-antiplasmin
• Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

Question 16

Principal inhibitor of plasminogen activation, inactivating both TPA and UPA, thus preventing them from converting plasminogen to the active fibrinolytic enzyme plasmin

Answer 16

Plasminogen Activator Inhibitor-1 (PAI-1)

Question 17

Synthesized in the liver and is the primary inhibitor of free plasmin (small amounts of plasmin is found in the blood)

Answer 17

Α2-antiplasmin

Question 18

• Synthesized in the liver
• Activated by the thrombin-thrombomodulin complex
• Activated TAFI: Functions as an anti-fibrinolytic enzyme (this enzyme cannot dissolved blood clot)

Answer 18

Thrombin Activatable Fibrinolysis Inhibitor (TAFI)