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MTAP 2 - HEMA 2 (trans) > Coagulation Cascade > Flashcards

Coagulation Cascade Flashcards

1
Q

Reaction system that begins with FXII and culminates in fibrin polymerization

A

Intrinsic Pathway

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2
Q

Known as the primary step in coagulation because this factor could be found in blood, whereas TF could not.

A

Activation of Factor XII

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3
Q

Factors involved in intrinsic pathway

A

XII, pre-K, HMWK, XI, IX, VIII, X, V, prothrombin (II), and fibrinogen (I)

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4
Q

Complex in the intrinsic pathway that is crucial to the activation of

A

Factor X

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5
Q

In vivo activation of FXII begins at the activation of

A

Contact Group

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6
Q

Induces the conversion/activation of HMWK into Bradykinin and FXII

A

Kallekrein

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7
Q

IN VITRO activation of FXII will begin when

A

Exposed to negatively charged surface (glass)

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8
Q

FXIIa or PK and HMWK will then activate

A

FXI to FXIa

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9
Q

This tenase or complex that will activate to FX to FXa in Intrinsic factor

A

IXa:VIIIa complex with the presence of calcium and phospholipid

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10
Q

All these factors in intrinsic pathway cause bleeding if affected EXCEPT for

A

Factor XII (no bleeding risk/tendency)

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11
Q

Lab test for Intrinsic pathway

A

PT, APTT (measure XII, XI, IX, VIII)

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12
Q

Formation of TF:VIIa has since proven to be the primary in vivo initiation mechanism for coagulation

A

Extrinsic Pathway

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13
Q

T/F: TF is not found on blood (released only if there is injury in the blood vessel)

A

TRUE

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14
Q

Factors involved in Extrinsic pathway

A

VII, X, V, prothrombin (II) and fibrinogen (I)

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15
Q

FVIIa will activate FX and FXa with

A

TF:VIIa (with the presence of calcium and phospolipid)

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16
Q

Where IF and EF meet

A

Common pathway

17
Q

Common pathway is composed of what factors?

A

FX, FV, FII (prothrombin), FI (fibrinogen)

18
Q

FXa binds with its cofactor FVa in the presence of calcium and phospholipid to form the Xa:Va complex, which will then convert

A

Prothrombin (FII) to thrombin (FIIa)

19
Q

Thrombin, in the presence of calcium activates

A
  • Fibrinogen to fibrin polymer (unstabilized)
  • FIIa Activates FXIII to FXIIIa (fibrin stabilizing factor)
20
Q

FXIIIa > Stabilize the unstable fibrin polymer which will result to

A

Cross-linked fibrin

21
Q
  • Occurs on tissue factor-expressing cells and produces 3% to 5% of the total thrombin generated
  • Happens in extrinsic pathway
A

Initiation phase

22
Q

Refers to extrinsic tenase complex formation and generation of small amounts of __

A

FXa, FIXa, and thrombin

23
Q

1%-2% - normally present in blood in activated form

A

FVIIa

24
Q

Provide tissue factor

A

Fibroblast & other sub-endothelial cells

25
Q

Cofactor to FVIIa

A

Tissue Factor

26
Q

Activates low levels of both FIX and FX

A

TF:VIIa

27
Q
  • Occurs on the platelets, which produces 95% or more of the total thrombin
  • Happens in intrinsic pathway
A

Propagation Phase

28
Q

Activated by thrombin in the initiation phase bind to platelet membranes and become receptors for FXa and FIXa

A

Cofactors FVa and FVIIa

29
Q

Generated in the initiation phase binds to FVIIIa on the platelet membrane to form the intrinsic tenase complex IXa:VIIIa

A

FIXa

30
Q

Activates prothrombin and generates a burst of thrombin

A

FXa binds to FVa to form the prothrombinase complex

31
Q
  • Cleaves fibrinogen into a fibrin clot
  • Activates factor XIII to stabilize the clot
  • Binds to thrombomodulin to activate the protein C control pathway
  • Activates TAFI to inhibit fibrinolysis
A

Thrombin (FIIa)

32
Q
  • Cleaves fibrinogen into a fibrin clot
  • Activates factor XIII to stabilize the clot
  • Binds to thrombomodulin to activate the protein C control pathway
  • Activates TAFI to inhibit fibrinolysis
A

Thrombin (FIIa)

MTAP 2 - HEMA 2 (trans) (7 decks)

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