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OB > FETOTOXIC AGENTS > Flashcards

FETOTOXIC AGENTS Flashcards

1
Q

Preterm infants: NEPHROTOXICITY and OTOTOXICITY

A

Aminoglycosides (Gentamicin OR Streptomycin)

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2
Q

GRAY BABY SYNDROME

NOT TERATOGENIC

A

Chloramphenicol

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3
Q

1st trimester: hypoplastic left heart syndrome, microphthalmia/anophthalmia, clefts and ASD

A

Nitrofurantoin

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4
Q

1st trimester: anencephaly, left ventricular outflow obstruction, choanal atresia, diaphragmatic hernia

A

Sulfonamides

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5
Q

> 25 weeks AOG: YELLOWISH BROWN DISCOLORATION OF DECIDUOUS TEETH

A

Tetracyclines

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6
Q

FEMALE - hypoplastic, T-shaped uterine cavity; cervical collars, breast cancer

MALE - epididymal cysts, hypospadias, cryptorchidism

A

SEX HORMONES

Diethylstilbestrol (DES)

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7
Q

Embryopathy (6th-9th week)

Stippling of vertebrae
Nasal hypoplasia
Choanal atresia

A

ANTICOAGULANT

Warfarin

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8
Q

CLOVER LEAF skull, wide nasal bridge, low set ears, micrognathia and limb abnormalities

A

Methotrexate

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9
Q

Irreversible HYPOTHYROIDISM

RISK of THYROID CA

A

Radioiodine

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10
Q

Fetal growth and behavioral abnormalities

CHILDHOOD DEVELOPMENTAL DELAY

A

Lead

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11
Q

Disturbances in NEURONAL CELL DIVISION and migration

Developmental delay, microcephaly and severe brain damage

AVOID: shark, king mackerel, swordfish, albacore tuna

A

Mercury

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12
Q

MOST POTENT TERATOGEN

Cranial-neural crest defects

A

Retinoids (Isotretinoin)

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13
Q

> 10 000 mIU/day causes defects

A

Retinol

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14
Q

NOT considered a major teratogen

NEONAYAL BEHAVIRAL SYNDROME: jitteriness, irritability, hyper or hypotonia, feeding abnormalities, vomiting, hypoglycemia, thermoregulatory instability and respiratory abnormalities

A

(Selective serotonin reuptake inhibitors) SSRI/ (serotonin and norepinephrine reuptake inhibitor) SNRI

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15
Q

ASD and VSD

A

SSRI - Paroxetine

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16
Q

EBSTEIN ANOMALY - apical displacement of tricuspid valve

hypothyroidism, diabetes insipidus, cardiomegaly, bradycardia, ECG abnormalities, cyanosis, hypotonia

A

Lithium

17
Q

NOT considered teratogenic

abnormal extrapyramidal muscle movements

WITHDRAWAL SYMPTOMS: agitation, abnormally increased or decreased muscle tone, tremor, sleepiness, feeding difficulty and respiratory abnormalities

A

ANTI-PSYCHOTICS

Haloperidol, Chlorpromazine, Fluphenazine, Clozapine, Olanzapine, Risperidone

OB (16 decks)

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