female reproductive hormones Flashcards
what are the two key cells associated with the ovarian follicle ?
theca cells
granulosa cells
what are the hormones associated with theca vs granulosa cells ?
theca cells stimulates by LH
granulosa is stimulated by FSH
what enzymes are activated by FSH and LH ?
desmolase activated by LH
aromatase is activated by FSH
what is the effect of estrogen on FSH and LH ?
decreases both FSH and LH secretion
what is progesterone made by ?
corpus luteum
what are the effects of progesterone ?
thickens the cervical mucous
prevents uterine contractions
raises body temperature
inhibits FSH and LH release
why is there an increased risk of endometrial carcinoma in post menopausal women ?
due to the unopposed estrogen levels
what is the mechanism of progestin only pills as a contraceptive ?
-suppress ovulation via negative feedback on FSH and LH
-thickens the cervical mucus
-thins the endometrium - to prevent implantation
what is medroxy progesterone ?
injectable progestin only
what are the benefits of adding estrogen to OCPs ?
- estrogen stabilizes the endometrium so less breakthrough bleeding
- better suppression of follicular growth
- estrogen increases the effect of progesterone
what are the complications associated with OCP ?
breakthrough bleeding
thrombosis
cancer
what are the contraindications associated with OCPS?
smokers above 35 years old
history of DVT and PE
