Female Repro System Flashcards

1
Q

What is in ovaries

A

Primordial follicle contains oogonium (stem cell which undergo mitotic division)
Produce primary oocytes
Born with all primordial follicle

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2
Q

How many chromosomes in primary oocyte

A

46

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3
Q

What causes release of haploid secondary oocyte

A

Ovulation

Extra genetic material released as polar body

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4
Q

When does second meiotic devisor between

A

When secondary oocyte fertilised by sperm

Second polar body released

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5
Q

What happens to primordial follicle when egg is released

A

Forms corpus leutuem (CL)

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6
Q

What are granulomosa cells

A

Produce oestrogen

Female sex hormone

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7
Q

What does GnRh do

A

Stimulate FSH and LH

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8
Q

What does FSH do

A

Stimulates one primordial follicle and primary oocyte ro grow and release egg
Stimulates sex hormones

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9
Q

What does LH do

A

Maintains dominant follicle that is growing
Induces ovulation
Stimulates CL
Stimulates sex hormones

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10
Q

What does oestrogen do

A

Supports secondary sexual characteristics

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11
Q

What does progesterone do and how is it produced

A

Produced from CL

Maintains secretary endometrium

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12
Q

When is there -ve feedback

A

If moderate level of oestrogen and progesterone

Avoids more than one egg production

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13
Q

What happens in -ve feedback

A

Inhibin from granulomasa cells inhibit FSH

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14
Q

When is there +Ve feedback

A

If high levels of oestrogen in absence of progesterone
During day 12-14
Causes LH surge to stimulate ovulation

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15
Q

What are the two phases of the ovarian cycle

A

Follicular

Luteal

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16
Q

What happens in the follicular phase

A
FSH and LH increase
Stimulate follicular growth 
Stimulates oestrogen production 
Negative feedback on FSH to prevent >1 egg 
Oestrogen gets to high enough level to stimulate +ve feedback 
LH surge 
Oocyte is released 
CL produces progesterone 
-ve feedback again
17
Q

What happens in the luteal phase

A

If no fertilisation CL will regress after 14 days
Leads to fall in hormones and HPG resets
If fertilisation occurs embryo produced BHCG which stimulates CL and keeps producing hormones

18
Q

How can you tell if someone is ovulating

A

14 days after ovulation is fairly set cycle

If progesterone high = ovulation occurred

19
Q

What are the two phases of the menstrual cycle

A

Proliferative

Secretory

20
Q

What happens in the proliferative stage

A

Oestrogen initiates Fallopian tube formation and thickening of endometrium ready for egg

21
Q

What happens in secretory phase

A

Progesterone stimulates thickening of womb
Dilates blood vessels
If no pregnancy at day 26 all homones drop = bleed

22
Q

Why is there high levels of LH and FSH in menopause

A

As trying to get ovaries to make eggs