Female Repro Physio

Question 0

What hormones act on granulosa cells?

Answer 0

LH and FSH

Question 1

What hormone acts on theca cells?

Answer 1

LH

Question 2

What is responsible for androgen synthesis?

Answer 2

Theca interna

Question 3

What is the rate limiting step of hormone synthesis?

Answer 3

LH stimulates conversion of cholesterol to pregnenolone

Question 4

What is the hormone synthesis pathway?

Answer 4

Pregnenolone to progesterone to androstenedione which is carried to granulosa cell

Question 5

What happens in granulosa cells?

Answer 5

Estrogen synthesis. Under FSH control, androstenedione converted by aromatase to estrone and estradiol. FSH also stimulates production of new LH receptors

Question 6

What happens in corpus luteum?

Answer 6

Theca derived cells make estrogen under influence of LH
Granulosa derived cells can produce androgen
Progesterone directly secreted

Question 7

How are steroid hormones transported?

Answer 7

Estradiol binds to shbg

Progesterone binds to CBG (corticosteroid binding globulin, transcortin)

Question 8

What are some of the effects of estrogen?

Answer 8

Help promote growth spurt and epiphyseal closure
Increase Hdl, decrease ldl
Fat deposition
Promote endometrial growth,