Female Physiology Flashcards
What is the pathway from the primordial follicle to the corpus luteum?
primordial follicle –> primary follicle –> formation of theca layers –> formation of antrum –> vesicular follicles –> mature follicle –> ovum with corona radiate –> corpus luteum
What follicle is the mature follicle that is ovulated?
Graafian follicle
What meotic phase is the primary follicle arrested in?
Prophase I
When the Graffian follicle is relased, what meotic phase it arrested in?
Prophase/metaphase II
What happens to the ovarian target cells under the stimulation of FSH and LH?
increase the cells rates of secretion and the growth/proliferation of the cells
On wha day of the ovarian cycle is there ovulation?
14th day
What is the main H that is secreted during the growth of the follicles?
Estrogen
What does estrogen do to FSH and LH levels?
Inhibits their release by a neg feedback on the ant pit
What are the 2 main H’s released by the corpus luteum?
Progestrone and Estrogen
What happens to FSH and LH levels once the corpus luteum degenerates?
they spike
At what day does the FSH and LH levels spike?
day 14 (Ovulation)
Which phase does progesterone dominate, where it has a large bell curve?
Luteal phase
Which H inhibits the secretion of FSH and LH, other than Estrogen?
Inhibin
Most of the time, E has negative feedback for LH and FSH, but what cahnges before ovulation?
It has a positive feedback –> preovulatory surge of LH –> ovulation
What H causes ↑ inhibitory effect of estrogen?
progesterone
What is the type of release of GnRH, is it constant or pulsatile?
Pulsatile
In what amounts is estrogen inhibitory to the production of LH and FSH?
Small
So high levels of estrogen do what on the ant pit?
Stimualtory
What are the effects of LH on the ovary?
Ovulation and subsequent development of and secretion by the corpus luteum
What happens to E, P and inhibin levels once the corpus luteum regresses into nothing?
They drop to a low ebb
Once they E, P, and I levels drop, what happens to FSH and levels?
They increase to as much as 2-fold.
The new rise of LH and FSH cause what to happen?
they initiate a new ovarian follicle to grow and progressive increase of estrogen to grow
During the ovarian phase, what stimulates the follicle to give rise to theca?
FSH
What theca forms additional P and E?
Theca interna
What does the theca externa fomr?
capsule of the developing follicle
After early proliferative growth, the follicular fluid with high E causes what to appear within the mass of granulosa cells?
Antrum
Once the antral follicle grows, how many follicles (from the original 6-12) grows?
only 1
prevents more than 1 child from developing
What H is required for the final follicular growth and ovulation?
LH
Which H maintains the endometrial lining?
Progesterone