Embryology Flashcards

1
Q

What is on the Y chromosome that turns on a # of genes to make u male?

A

Testis-determining factor (TDF)

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2
Q

What happens at week 6 in gonad development at the genital ridge?

A

Germ cells arrive

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3
Q

What happens if germ cells dont arrive at the genital ridge?

A

No development of the gonads

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4
Q

What is the morphology of the gonade before the germ cells arrive, when the there are pairs of longitudinal ridges?

A

Indifferent gonads

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5
Q

What gene encodes TDF?

A

SRY

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6
Q

What 3 things does TDF do?

A
  1. proliferates sex cord to form testis
  2. cords grow in a network towards hilum to give rise to the rete testis
  3. tunical albugenia separates cords from surface epithelium
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7
Q

Where do the eminiferous tubules, straight tubules, rete testis, and mesenchymal cells come from?

A

Seminiferous cords

which are from the sex cords

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8
Q

Enlargement of the testes, atrophy of the mesonephic kidney and paramesonephric ducts, and enlargement of the processus vaginal cases what to occur?

A

Descent of the testis

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9
Q

By what weke do the testis come from the lumbar region –> deep inguinal ring?

A

week 26

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10
Q

What anchors the testes to the anterior abd wall?

A

Gubernaculum

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11
Q

What is the envagination fo the peritoneal cavity through the anterior abd wall that forms the inguinal canal, and that the testes follow into out of the abdomen?

A

Processsus vaginalis

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12
Q

What is teh remnant of the peritoneum that gets cut off the peritoneum and enters the scrotum to surround the testes?

A

Tunica vaginalis

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13
Q

What happens to the primative sex cords in women?

A

They disappear

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14
Q

What does the surface epithelium penetrate once it proliferates and turns into cortical cords?

A

Underlying mesenchyme

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15
Q

THe cortical cords later split into isolated cell clusters that surroudn the rimative germ cells, which give rise to what?

A

Oogonia

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16
Q

What is the term for the persistent processus vaginalis in female?

A

Canal of Nuck

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17
Q

What are the germ cells of the male?

A

Sperm

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18
Q

What are the germ cells of the female?

A

Oogonia

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19
Q

What is the mesenchyme (support) of the male?

A

Leydig cells

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20
Q

What is the mesenchyme (support) of the female?

A

Ovarian stroma

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21
Q

What is the coelomic epithelium of the male?

A

Seminiferous tubules/Sertoli cells

22
Q

What is the coelomic epithelium of the female?

A

Follicle cells

23
Q

What are the 2 indifferent duct systems that are present int eh developing embryo until week 5-6?

A

Mesonephric (wolffian)

Paramesonephric (mullerian)

24
Q

What duct forms in males and is the duct of the itnermediate kidney?

A

Wolffian

wolf man

25
Q

What duct form in females and is a longitudinal derivative of the epithelium of th eurogenital ridge?

A

Mullerian

mullerian mom

26
Q

What H untimately control the development of the genital ducts?

A

TDF

27
Q

What H is produced by leydig cells, and stimulates the continued developemnt of the mesonephric ducts and tubules?

A

Testosterone

28
Q

What H is produced by sertoli cells and inhibits the development of the mullerian duct?

A

MIF

29
Q

What are the 4 derivatives from the mesonephric ducts?

A

Epididymus
Vas deferens
Ejaculatory duct
Seminal vesicle

30
Q

What are the 2 structures that form from the regression of the Mullerian ducts?

A

Appendix of the testis

Prostatic utricle

31
Q

Lack of what H cause the mesonpehric ducts to regress in women?

A

testosterone

32
Q

Lack of what H cause the Mullerian ducts to form the main genital ducts in women?

A

MIF

33
Q

What are the 3 derivated of the paramesonephric duts in women?

A

uterine tubes
uterus
Superior part of the vagina

34
Q

The Epoopoohorona nd Paroophoron are remantns of what?

A

Mesnephric ducts

35
Q

This is the cyst which are scattering of tiny remnants of the mesonephric duct that remain near the vagina.

A

Gartner’s cyst

36
Q

This is the conditon where there germ cells degenrate after reaching the gonadal ridge –> ovarian streaks –> infantile genitalia in women.

A

Turner syndrome

45XO

37
Q

This is the extremely rate hermaphrodite that are 46XX, ahve both testicular and ovarian tissue, and ambiguous external genitalia.

A

True hermaphrodite

38
Q

What causes male hermaphrodites (46XY)?

A

Inadequate testosterone and MIF

39
Q

What causes female hermaphrodites (46XX), where there is masculization of the external genitalia?

A

Exposure of the female fetus to excessive levels of androgens
CAH

40
Q

What is the condition where a male has small testes, tall, long lower limbs, gynecomasetia, and is sometimes MR?

A

Klinefelters syndrome

47XXY

41
Q

What is the rare conditon where there is a defect in the androgen R, leading to 46XY males but appear as normal females?

A

Androgen insensitivity syndrome

testicular feminization sydnrome

42
Q

What is the conditionw here the processus vaginalis doesn close and accumulate fluid?

A

Hydrocele

43
Q

What is the term for undescended testes?

A

Cryptorchidism

44
Q

What is the term for intestinal loops that protrude through a persistent processus vaginalis?

A

Congenital indirect inguinal hernia

45
Q

What is the term where there are 2 vaginas leading to 2 uteri?

A

Uterus didelphys withb a double vagina

46
Q

What is teh term for 2 uteri, which are separated by a septum like the heart ventricles?

A

Uterus vicornis

47
Q

What is the term for only 1 side of the uterus developing?

A

Uterus unicornate

48
Q

What is the term for a normal uterus but no opening to the external vagina?

A

Vaginal atresia

49
Q

What is the term for an external urethral opening on the vetnral aspect of the penis?

A

Hypospadias

50
Q

What is the term for an external urethral opening on the dorsal aspect of the penis?

A

Epispadias

51
Q

What is the term if you happened to be nicknamed “Johnson & Johnson”?

A

Bifid/double penis