Embryology Flashcards

1
Q

What is on the Y chromosome that turns on a # of genes to make u male?

A

Testis-determining factor (TDF)

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2
Q

What happens at week 6 in gonad development at the genital ridge?

A

Germ cells arrive

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3
Q

What happens if germ cells dont arrive at the genital ridge?

A

No development of the gonads

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4
Q

What is the morphology of the gonade before the germ cells arrive, when the there are pairs of longitudinal ridges?

A

Indifferent gonads

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5
Q

What gene encodes TDF?

A

SRY

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6
Q

What 3 things does TDF do?

A
  1. proliferates sex cord to form testis
  2. cords grow in a network towards hilum to give rise to the rete testis
  3. tunical albugenia separates cords from surface epithelium
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7
Q

Where do the eminiferous tubules, straight tubules, rete testis, and mesenchymal cells come from?

A

Seminiferous cords

which are from the sex cords

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8
Q

Enlargement of the testes, atrophy of the mesonephic kidney and paramesonephric ducts, and enlargement of the processus vaginal cases what to occur?

A

Descent of the testis

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9
Q

By what weke do the testis come from the lumbar region –> deep inguinal ring?

A

week 26

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10
Q

What anchors the testes to the anterior abd wall?

A

Gubernaculum

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11
Q

What is the envagination fo the peritoneal cavity through the anterior abd wall that forms the inguinal canal, and that the testes follow into out of the abdomen?

A

Processsus vaginalis

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12
Q

What is teh remnant of the peritoneum that gets cut off the peritoneum and enters the scrotum to surround the testes?

A

Tunica vaginalis

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13
Q

What happens to the primative sex cords in women?

A

They disappear

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14
Q

What does the surface epithelium penetrate once it proliferates and turns into cortical cords?

A

Underlying mesenchyme

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15
Q

THe cortical cords later split into isolated cell clusters that surroudn the rimative germ cells, which give rise to what?

A

Oogonia

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16
Q

What is the term for the persistent processus vaginalis in female?

A

Canal of Nuck

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17
Q

What are the germ cells of the male?

A

Sperm

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18
Q

What are the germ cells of the female?

A

Oogonia

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19
Q

What is the mesenchyme (support) of the male?

A

Leydig cells

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20
Q

What is the mesenchyme (support) of the female?

A

Ovarian stroma

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21
Q

What is the coelomic epithelium of the male?

A

Seminiferous tubules/Sertoli cells

22
Q

What is the coelomic epithelium of the female?

A

Follicle cells

23
Q

What are the 2 indifferent duct systems that are present int eh developing embryo until week 5-6?

A

Mesonephric (wolffian)

Paramesonephric (mullerian)

24
Q

What duct forms in males and is the duct of the itnermediate kidney?

A

Wolffian

wolf man

25
What duct form in females and is a longitudinal derivative of the epithelium of th eurogenital ridge?
Mullerian | mullerian mom
26
What H untimately control the development of the genital ducts?
TDF
27
What H is produced by leydig cells, and stimulates the continued developemnt of the mesonephric ducts and tubules?
Testosterone
28
What H is produced by sertoli cells and inhibits the development of the mullerian duct?
MIF
29
What are the 4 derivatives from the mesonephric ducts?
Epididymus Vas deferens Ejaculatory duct Seminal vesicle
30
What are the 2 structures that form from the regression of the Mullerian ducts?
Appendix of the testis | Prostatic utricle
31
Lack of what H cause the mesonpehric ducts to regress in women?
testosterone
32
Lack of what H cause the Mullerian ducts to form the main genital ducts in women?
MIF
33
What are the 3 derivated of the paramesonephric duts in women?
uterine tubes uterus Superior part of the vagina
34
The Epoopoohorona nd Paroophoron are remantns of what?
Mesnephric ducts
35
This is the cyst which are scattering of tiny remnants of the mesonephric duct that remain near the vagina.
Gartner's cyst
36
This is the conditon where there germ cells degenrate after reaching the gonadal ridge --> ovarian streaks --> infantile genitalia in women.
Turner syndrome 45XO
37
This is the extremely rate hermaphrodite that are 46XX, ahve both testicular and ovarian tissue, and ambiguous external genitalia.
True hermaphrodite
38
What causes male hermaphrodites (46XY)?
Inadequate testosterone and MIF
39
What causes female hermaphrodites (46XX), where there is masculization of the external genitalia?
Exposure of the female fetus to excessive levels of androgens CAH
40
What is the condition where a male has small testes, tall, long lower limbs, gynecomasetia, and is sometimes MR?
Klinefelters syndrome 47XXY
41
What is the rare conditon where there is a defect in the androgen R, leading to 46XY males but appear as normal females?
Androgen insensitivity syndrome | testicular feminization sydnrome
42
What is the conditionw here the processus vaginalis doesn close and accumulate fluid?
Hydrocele
43
What is the term for undescended testes?
Cryptorchidism
44
What is the term for intestinal loops that protrude through a persistent processus vaginalis?
Congenital indirect inguinal hernia
45
What is the term where there are 2 vaginas leading to 2 uteri?
Uterus didelphys withb a double vagina
46
What is teh term for 2 uteri, which are separated by a septum like the heart ventricles?
Uterus vicornis
47
What is the term for only 1 side of the uterus developing?
Uterus unicornate
48
What is the term for a normal uterus but no opening to the external vagina?
Vaginal atresia
49
What is the term for an external urethral opening on the vetnral aspect of the penis?
Hypospadias
50
What is the term for an external urethral opening on the dorsal aspect of the penis?
Epispadias
51
What is the term if you happened to be nicknamed "Johnson & Johnson"?
Bifid/double penis