Female Genital Pathology (Duval) Flashcards

1
Q

Describe lichen sclerosus (pathology)

A
  • Thinning of epidermis, loss of rete pegs
  • Hyperkeratosis
  • Dermal fibrosis
  • Scant dermal mononuclear inflammation
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2
Q

Describe lichen simplex chronicus (pathology)

A
  • Epithelial thickening w/mitoses
  • Hyperkeratosis
  • Dermal leukocytosis
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3
Q

What is condylomata acuminata (pathology)?

A
  • Vulvar tumor
  • Usually multiple
  • Elevated papillary or flat rugose
  • HPV 6, 11
  • Koilocytosis (hallmark of HPV infection)
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4
Q

What is the hallmark of HPV infection (pathology)?

A

Koilocytosis

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5
Q

What type are most vulvar carcinomas?

A

90% squamous cell carcinoma

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6
Q

Congenital anomalies of the vagina

A
  • Total absence of vagina
  • Septate or double vagina
  • Gartner’s duct cysts
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7
Q

Describe vaginal clear cell adenocarcinoma

A

Rare cancer MC caused by DES exposure

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8
Q

What are cervical “erosions”?

A

Inflamed appearance of exocervix of young adult females due to downward migration of squamocolumnar junction

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9
Q

Low risk HPV types

A

6, 11, 42, 44

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10
Q

High risk HPV types

A

16, 18, 31, 45

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11
Q

What is the regurgitation theory of endometriosis?

A

Menstrual back flow through fallopian tubes followed by implantation

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12
Q

What is the metaplastic theory of endometriosis?

A

Endometrial differentiation of coelomic epithelium

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13
Q

Morphology of endometriosis

A
  • Red blue to yellow brown serosal nodules
  • Chocolate cysts
  • Glands plus stroma plus hemosiderin
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14
Q

What is dysfunctional uterine bleeding and what is it caused by?

A
  • Abnormal bleeding without organic lesion

- Caused by relative excess of estrogen or relative lack of progesterone

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