Feline cutaneous reaction patterns and pruritus Flashcards

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1
Q

Describe the pathogenesis of feline cutaneous reaction patterns

A
  • skin barrier dysfunction
  • immune dysregulation and allergen sensitisation
  • environmental factors
  • stress
  • microbes
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2
Q

What is feline atopic syndrome

A

Allergic disease associated with environmental allergens, food allergy and asthma that may be associated with IgE antibodies

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3
Q

What is feline atopic skin syndrome?

A

Inflammatory and pruritic dermatitis involving a spectrum of non-specific cutaneous reaction patterns (CRPS), that may be associated with IgE to environmental allergens

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4
Q

What is a food allergy?

A

Any disease, including FASS, attributable to immunological reactivity to ingested food items

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5
Q

Which 2 cells are involved in a feline atopic syndrome response?

A

Eosinophils

Lymphocytes

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6
Q

What is the main difference between extrinsic and intrinsic feline atopic syndrome?

A

Extrinsic disease: pathogenesis involves IgE and is demonstrable (via allergy testing)
Intrinsic disease: same clinical signs, no demonstrable IgE

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7
Q

Describe the typical features of a history takes from a patient with feline atopic skin syndrome

A
  • Young age at onset (6m–3y)
  • Presence of pruritus
  • Absence of contagion
  • Response to corticosteroids
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8
Q

What are the characteristics of FASS lesions?

A
  • Pruritis
  • Erythematous papules
  • Excoriations
  • Lichenification
  • Hyperpigmentation
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9
Q

Where are lesions distributed in FASS?

A
  • Ears
  • Eyes
  • chin
  • footpads
  • ventral abdomen
  • tail base
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10
Q

Before FASS is conformed as the diagnoses what 4 differentials must be eliminated?

A
  • Flea/flea allergy
  • Parasites
  • infections
  • food allergy
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11
Q

How can pruritis be confirmed in the cat when it is not observed?

A

Look for evidence of self-trauma

  • Linear excoriations
  • Short, spikey hairs on examination
  • Vomiting fur balls
  • Hair in faeces
  • Embedded hair in gingival sulci and/or tongue
  • Clumps of hair in cat’s environment
  • Trichogram: broken/frayed tips
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12
Q

What are the two causes of non-pruritic self induced alopecia?

A

Anxiety

Pain e.g. uti, orthopaedic

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13
Q

What are the signs of self-induced alopecia?

A
  • Non inflamed (macroscopically)
  • Areas cat can reach (symmetrical)
  • Ventral abdomen, lateral thorax, caudal thighs
  • Often linear
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14
Q

How is miliarry dermatitis characterised?

A
  • Multiple crusted papules, very pink
  • Dorsum
  • (Caudomedial thighs, ventral abdomen)
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15
Q

Which 3 lesions make up an eosinophilic granuloma complex?

A
  • Eosinophilic plaque
  • Eosinophilic granuloma
  • Indolent ulcer
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16
Q

What is an eosinophilic plaque? Where do they occur?

A
  • Highly pruritic
  • Raised, alopecic, erythematous, eroded to ulcerated plaque
  • Abdominal and inguinal skin
  • Medial and caudal thighs
  • Interdigital skin
  • Neck
17
Q

What is an eosinophilic granuloma?

A
  • Pruritus variable
  • Alopecic, raised plaque/nodule
  • Intact skin or eroded-ulcerated: ulcerated lesions central white accumulations
18
Q

Where do eosinophilic granulomas occur?

A
  • Caudal thighs
  • Hard/soft palate +/- necrosis
  • Swelling of chin (asymptomatic)
19
Q

What is an indolent ulcer?

A
  • Non-pruritic
  • Non-painful
  • Well circumscribed, red/brown ulcer with raised border
  • Found on the upper lip
20
Q

Give some examples of diagnostic tests that allow ruling out of differential diagnosis for FASS

A
  • Direct/indirect impression smear cytology
  • Flea combing
  • Scale examinations
  • Skin scrapings
  • Trichography
  • Dermatophyte culture
  • Trial treatment – Demodex gatoi
21
Q

Describe a flea eradication trial

A

Treat all cats and contacts with flea treatment
Trial lasts 6-8 weeks
Use an adulticide with a rapid speed of kill

22
Q

Describe a food elimination diet

A
  • lasts 8-12 weeks
  • Novel home cooked diet
  • Commercial novel hydrolysed or single protein diet
  • Re-challenge with previous foods over two weeks
  • Re-stabilise with trial diet confirms diagnosis
23
Q

What are the 4 components of multimodal management of FAS?

A
  • Skin barrier care
  • Anti-inflammatories to control skin inflammation
  • Allergen avoidance
  • Control flare factors e.g. regular Ectoparasiticides, reduce stress
24
Q

What are some recommended treatments for FAS?

A
  • systemic glucocorticoids
  • ciclosporin
  • topical glucocorticoids
25
Q

What is the purpose of allergen specific immunotherapy?

A

Reduce flares associated with exposure to environmental allergens

26
Q

What factors need to be considered when treating FAS?

A
Patient factors:
- severity of disease
- general health status
- home environment
- treatment administration (temperament)
Client factors:
- financial constraints
- treatment administration (time, physical constraints)
27
Q

Name 2 glucocorticoid drugs used as anti-inflammatories/ immunomodulators in FAS

A

Prednisolone

Dexamethasone

28
Q

What are some of Favrot’s criteria for FASS diagnosis?

A
  • at least 2 body sites affected
  • 2/4 of the feline cutaneous reaction patterns
  • symmetrical alopecia
  • erosions/ulcerations on the chin
  • no lesions on the rump
  • pruritis at onset