Feeding and Satiety Flashcards
What BMI is classed as obese?
BMI of 30.0 - 39.9
What BMI is classed as morbidly obese?
40 or more
Which hypothalamus caused obesity?
lesioning ventromedial
Which hypothalamus caused leaness?
lesioning lateral
What is satiation?
sensation of fullness generated during a meal
What is satiety?
period of time between termination of one meal and the initiation of next
Which hormones are satiation signals?
Cholecystokinin (CCK) – secreted from enteroendocrine cells in duodenum and jejunum
Peptide YY (PYY3-36) – secreted from endocrine mucosal L-cells of G-I tract
Glucagon-like peptide 1 (GLP-1) – product of pro-glucagon gene. Also released from L cells
Oxyntomodulin (OXM)
Obestatin – peptide
What is ghrelin?
a hunger signal
What do monoamines do?
act to suppress food intake
What do Glutamate, Gaba and opioids do?
increase food intake
Which two hormones report fat status to brain?
Leptin - made & released from fat cells
Insulin - made & released from pancreatic cells
What happens to insulin and leptin levels as more fat is stored?
Levels in blood increase as more fat is stored
What kind of hormone is leptin?
PLEIOTROPIC
What is use of leptin therapeutically limited by ?
leptin resistance present in most obese individuals
How does Sibutramine work?
Selectively inhibits re-uptake of noradrenaline, 5-HT and dopamine
