Feb 5th- Apr 7th

Question 2

what are the two types of sensitization

Answer 2

peripheral and central

Question 3

peripheral sensitization

Answer 3

• occurs in the peripheral nerve fibres (peripheral ends of nociceptors)
• neurochemical in nature
• related to substances released into injured tissue
• molecules activate nociceptors to fire more than tissue damage would predict

Question 4

central sensitization

Answer 4

• occurs in the central nervous system (spinal cord and brain)
• can happen at:
• DRG (dorsal root ganglion)
• spinal cord terminals of nociceptors
• second order neurons
• higher brain centres