Fatty Acid Oxidation

Question 1

Carnitine shuttle

Answer 1

Help transport larger fatty acids (acyl coA) in and out of the mitochondria, requires ATP and coA

Question 2

B oxidation

Answer 2

Chopping of one c-c unit after another. Acetyl coAs produced can directly enter Krebs. Require ATP
Produces PP

Question 3

Palmitate

Answer 3

16 c chain
Cleaved seven times
Creates 8 FA coA 7 ATP
Cannot synthesize glucose 
Noncarb

Question 4

Ultimate source of carbons in FA synthesis

Answer 4

Acetyl coA

Question 5

Acyl carrier protein

Answer 5

Acyl intermediates that are thioesters of a low molecular weight protein

Question 6

What is essential in FA synthesis

Answer 6

CO2 HCO3

Question 7

For every 2 carbons in FA syn, you need

Answer 7

2 NADPH

ATP

Question 8

During the synthesis of palmitate in liver

Answer 8

B keto residue is reduced to a saturated residue by NADPH

Question 9

Acetyl coA carboxylase

Answer 9

Catalyze rate limiting step in FA syn
Requires biotin
Inhibited by cAMP
Responds to changes in fat in diet

Question 10

Oxidation of Isoleucine (odd # chains)

Answer 10

Biotin dependent

Respond to B12

Question 11

Lipid oxidation steps (FA)

Answer 11

Hydrolysis 
Joining to coA
Reaction with carnitine
Oxidation by NAD
Hydration
Thiolysis

Question 12

Lipoprotein lipase

Answer 12

Hydrolyzes TAGs of plasma lipoproteins to supply FA to tissues

Question 13

How are FA oxidation and synthesis controlled

Answer 13

Occur in different cellular compartments

Employ different electron carriers