FA - Pharm - Drug reactions Flashcards
Coronary vasospasm
cocaine
sumatriptan
ergot alkaloids
cutaneous flushing
VANC: vancomycin adenosine niacin Ca channel blockers
dilated cardiomyopathy
doxorubicin (adriamycin)
daunorubicin
torsades do pointes
antiarrhythmics: class III (sotalol) and class IV (quinidine)
agranulocytosis
clozapine carbamazepine colchicine propylthiouracil methimazole dapsone
“Agranulocytosis Could Certainly Cause Pretty Major Damage”
aplastic anemia
chloramphenicol benzene NSAIDs propylthiouracil methimazole
direct Coombs-positive hemolytic anemia
methyldopa
penicillin
gray-baby syndrome
chloramphenicol
hemolysis in G6PD-deficient patients
Isoniazid (INH) sulfonamides primaquine aspirin ibuprofen nitrofurantoin
“hemolysis IS PAIN”
megaloblastic anemia
phenytoin
methotrexate
sulfa drugs
“having a Blast with PMS”
thrombotic complications
OCPs (oral contraceptives, e.g. estrogen)
cough
ACE inhibitors
note: ARBs like losartan -> no cough
pulmonary fibrosis
bleomycin
amiodarone
busulfan
“it’s hard to BLAB when you have pulmonary fibrosis”
jaundice
erythromycin
Q: why?
A: because it causes acute cholestatic hepatitis
hepatic necrosis
halothane
amanita phalloides
valproic acid
acetaminophen
liver “HAVAc” -> can cause focal to massive hepatic necrosis
hepatitis
isoniazid (INH)
pseudomembranous cholitis
clindamycin
ampicillin
adrenocortical insufficiency
glucocorticoid withdrawal (HPA suppression)
gynecomastia
spironolactone digitalis cimetidine alcohol (chronic) estrogens ketoconazole
“Some Drugs Create Awkward Knockers”
hot flashes
tamoxifen
clomiphene
hyperglycemia
niacin tacrolimus protease inhibitors hydrochlorothiazide (HCTZ) corticosteroids
hypothyroidism
lithium
amiodarone
sulfonamides
fat redistribution
glucocorticoids
protease inhibitors
gingival hyperplasia
phenytoin
verapamil
gout
furosemide
thiazides
niacin
cyclosporine
myopathies
fibrates niacin colchicine hydroxychloroquine interferon-alpha penicillamine statins glucocorticoids
“Fish N CHIPS Give you myopathies”
osteoporosis
corticosteroids
heparin
photosensitivity
sulfonamides
amiodarone
tetracycline
“SAT for a photo”
rash (Stevens-Johnson syndrome)
penicillin ethosuximide carbamazipine sulfa drugs lamotrigine allopurinol phenytoin phenobarbital
“bad rash after a PEC SLAPP”
SLE-like syndrome
hydralazine
isoniazid
procainamide
phenytoin
“it’s not HIPP to have lupus”
teeth (kids)
tetracyclines
tendonitis, tendon rupture, cartilage damage
fluoroquinolones
diabetes insipidus
lithium
demeclocycline
Fanconi’s syndrome
expired tetracycline
hemorrhagic cystitis
cyclophosphamide
ifosfamide (prevent by coadministration with mesna)
interstitial nephritis
methicillin
NSAIDS
furosemide
cinchonism
quinidine
quinine
cinchonism (from wiki): flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, rashes, vertigo, dizziness, dysphoria, nausea, vomiting and diarrhea;
worse with large dose
parkinson-like syndrome
antipsychotics
reserpine
metoclopramide
seizure
isoniazid bupropion imipenem/cilastatin tramadol enflurane metoclopramide
“with seizures, I BITE My tongue”
tardive dyskinesia
antipsychotics
antimuscarinic
atropine
TCAs
H1-blockers
neuroleptics
disulfiram-like reaction
metronidazole certain cephalosporins procarbazine 1st gen sulfonylureas (chlorpropamide, tolbutamide, glyburide) bactrim
disulfiram-like reaction: with alcohol, drug causes severe flushing, tachycardia, hypotension
nephrotoxicity/ototoxicity
aminoglycosides
vancomycin
loop diuretics
cisplatin
