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Boards study > FA - Pharm - Drug reactions > Flashcards

FA - Pharm - Drug reactions Flashcards

1
Q

Coronary vasospasm

A

cocaine
sumatriptan
ergot alkaloids

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2
Q

cutaneous flushing

A 
VANC:
vancomycin
adenosine
niacin
Ca channel blockers
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3
Q

dilated cardiomyopathy

A

doxorubicin (adriamycin)

daunorubicin

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4
Q

torsades do pointes

A 
antiarrhythmics:
class III (sotalol) and 
class IV (quinidine)
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5
Q

agranulocytosis

A 
clozapine
carbamazepine
colchicine
propylthiouracil
methimazole
dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

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6
Q

aplastic anemia

A 
chloramphenicol
benzene
NSAIDs
propylthiouracil
methimazole
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7
Q

direct Coombs-positive hemolytic anemia

A

methyldopa

penicillin

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8
Q

gray-baby syndrome

A

chloramphenicol

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9
Q

hemolysis in G6PD-deficient patients

A 
Isoniazid (INH)
sulfonamides
primaquine
aspirin
ibuprofen
nitrofurantoin

“hemolysis IS PAIN”

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10
Q

megaloblastic anemia

A

phenytoin
methotrexate
sulfa drugs

“having a Blast with PMS”

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11
Q

thrombotic complications

A

OCPs (oral contraceptives, e.g. estrogen)

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12
Q

cough

A

ACE inhibitors

note: ARBs like losartan -> no cough

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13
Q

pulmonary fibrosis

A

bleomycin
amiodarone
busulfan

“it’s hard to BLAB when you have pulmonary fibrosis”

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14
Q

jaundice

A

erythromycin

Q: why?
A: because it causes acute cholestatic hepatitis

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15
Q

hepatic necrosis

A

halothane
amanita phalloides
valproic acid
acetaminophen

liver “HAVAc” -> can cause focal to massive hepatic necrosis

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16
Q

hepatitis

A

isoniazid (INH)

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17
Q

pseudomembranous cholitis

A

clindamycin

ampicillin

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18
Q

adrenocortical insufficiency

A

glucocorticoid withdrawal (HPA suppression)

19
Q

gynecomastia

A 
spironolactone
digitalis
cimetidine
alcohol (chronic)
estrogens
ketoconazole

“Some Drugs Create Awkward Knockers”

20
Q

hot flashes

A

tamoxifen

clomiphene

21
Q

hyperglycemia

A 
niacin
tacrolimus
protease inhibitors
hydrochlorothiazide (HCTZ)
corticosteroids
22
Q

hypothyroidism

A

lithium
amiodarone
sulfonamides

23
Q

fat redistribution

A

glucocorticoids

protease inhibitors

24
Q

gingival hyperplasia

A

phenytoin

verapamil

25
Q

gout

A

furosemide
thiazides
niacin
cyclosporine

26
Q

myopathies

A 
fibrates
niacin
colchicine
hydroxychloroquine
interferon-alpha
penicillamine
statins
glucocorticoids

“Fish N CHIPS Give you myopathies”

27
Q

osteoporosis

A

corticosteroids

heparin

28
Q

photosensitivity

A

sulfonamides
amiodarone
tetracycline

“SAT for a photo”

29
Q

rash (Stevens-Johnson syndrome)

A 
penicillin
ethosuximide
carbamazipine
sulfa drugs
lamotrigine
allopurinol
phenytoin
phenobarbital

“bad rash after a PEC SLAPP”

30
Q

SLE-like syndrome

A

hydralazine
isoniazid
procainamide
phenytoin

“it’s not HIPP to have lupus”

31
Q

teeth (kids)

A

tetracyclines

32
Q

tendonitis, tendon rupture, cartilage damage

A

fluoroquinolones

33
Q

diabetes insipidus

A

lithium

demeclocycline

34
Q

Fanconi’s syndrome

A

expired tetracycline

35
Q

hemorrhagic cystitis

A

cyclophosphamide

ifosfamide (prevent by coadministration with mesna)

36
Q

interstitial nephritis

A

methicillin
NSAIDS
furosemide

37
Q

cinchonism

A

quinidine
quinine

cinchonism (from wiki): flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, rashes, vertigo, dizziness, dysphoria, nausea, vomiting and diarrhea;
worse with large dose

38
Q

parkinson-like syndrome

A

antipsychotics
reserpine
metoclopramide

39
Q

seizure

A 
isoniazid
bupropion
imipenem/cilastatin
tramadol
enflurane
metoclopramide

“with seizures, I BITE My tongue”

40
Q

tardive dyskinesia

A

antipsychotics

41
Q

antimuscarinic

A

atropine
TCAs
H1-blockers
neuroleptics

42
Q

disulfiram-like reaction

A 
metronidazole
certain cephalosporins
procarbazine
1st gen sulfonylureas (chlorpropamide, tolbutamide, glyburide)
bactrim

disulfiram-like reaction: with alcohol, drug causes severe flushing, tachycardia, hypotension

43
Q

nephrotoxicity/ototoxicity

A

aminoglycosides
vancomycin
loop diuretics
cisplatin

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