FA - Pharm - Drug reactions Flashcards by Justin Haseltine

Coronary vasospasm

cocaine
sumatriptan
ergot alkaloids

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cutaneous flushing

VANC:
vancomycin
adenosine
niacin
Ca channel blockers

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dilated cardiomyopathy

doxorubicin (adriamycin)

daunorubicin

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torsades do pointes

antiarrhythmics:
class III (sotalol) and 
class IV (quinidine)

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agranulocytosis

clozapine
carbamazepine
colchicine
propylthiouracil
methimazole
dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

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aplastic anemia

chloramphenicol
benzene
NSAIDs
propylthiouracil
methimazole

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direct Coombs-positive hemolytic anemia

methyldopa

penicillin

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gray-baby syndrome

chloramphenicol

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hemolysis in G6PD-deficient patients

Isoniazid (INH)
sulfonamides
primaquine
aspirin
ibuprofen
nitrofurantoin

“hemolysis IS PAIN”

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megaloblastic anemia

phenytoin
methotrexate
sulfa drugs

“having a Blast with PMS”

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thrombotic complications

OCPs (oral contraceptives, e.g. estrogen)

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cough

ACE inhibitors

note: ARBs like losartan -> no cough

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pulmonary fibrosis

bleomycin
amiodarone
busulfan

“it’s hard to BLAB when you have pulmonary fibrosis”

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jaundice

erythromycin

Q: why?
A: because it causes acute cholestatic hepatitis

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hepatic necrosis

halothane
amanita phalloides
valproic acid
acetaminophen

liver “HAVAc” -> can cause focal to massive hepatic necrosis

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hepatitis

isoniazid (INH)

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pseudomembranous cholitis

clindamycin

ampicillin

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adrenocortical insufficiency

glucocorticoid withdrawal (HPA suppression)

gynecomastia

spironolactone
digitalis
cimetidine
alcohol (chronic)
estrogens
ketoconazole

“Some Drugs Create Awkward Knockers”

hot flashes

tamoxifen

clomiphene

hyperglycemia

niacin
tacrolimus
protease inhibitors
hydrochlorothiazide (HCTZ)
corticosteroids

hypothyroidism

lithium
amiodarone
sulfonamides

fat redistribution

glucocorticoids

protease inhibitors

gingival hyperplasia

phenytoin

verapamil

gout

furosemide thiazides niacin cyclosporine

myopathies

``` fibrates niacin colchicine hydroxychloroquine interferon-alpha penicillamine statins glucocorticoids ``` "Fish N CHIPS Give you myopathies"

osteoporosis

corticosteroids | heparin

photosensitivity

sulfonamides amiodarone tetracycline "SAT for a photo"

rash (Stevens-Johnson syndrome)

``` penicillin ethosuximide carbamazipine sulfa drugs lamotrigine allopurinol phenytoin phenobarbital ``` "bad rash after a PEC SLAPP"

SLE-like syndrome

hydralazine isoniazid procainamide phenytoin "it's not HIPP to have lupus"

teeth (kids)

tetracyclines

tendonitis, tendon rupture, cartilage damage

fluoroquinolones

diabetes insipidus

lithium | demeclocycline

Fanconi's syndrome

expired tetracycline

hemorrhagic cystitis

cyclophosphamide | ifosfamide (prevent by coadministration with mesna)

interstitial nephritis

methicillin NSAIDS furosemide

cinchonism

quinidine quinine cinchonism (from wiki): flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, rashes, vertigo, dizziness, dysphoria, nausea, vomiting and diarrhea; worse with large dose

parkinson-like syndrome

antipsychotics reserpine metoclopramide

seizure

``` isoniazid bupropion imipenem/cilastatin tramadol enflurane metoclopramide ``` "with seizures, I BITE My tongue"

tardive dyskinesia

antipsychotics

antimuscarinic

atropine TCAs H1-blockers neuroleptics

disulfiram-like reaction

``` metronidazole certain cephalosporins procarbazine 1st gen sulfonylureas (chlorpropamide, tolbutamide, glyburide) bactrim ``` disulfiram-like reaction: with alcohol, drug causes severe flushing, tachycardia, hypotension

nephrotoxicity/ototoxicity

aminoglycosides vancomycin loop diuretics cisplatin