BRS Biochem - Oxidative Metab

Question 1

this fish poison complexes with NADH dehydrogenase, preventing NADH from transferring electrons to the electron transport chain for the production of ATP

Answer 1

Rotenone

however, rotenone does not block the transfer of electrons by FADH2 at the level of coenzyme Q

Question 2

this compound binds to the Fe3+ of cytochrome aa3 and inhibits complex IV of the electron transport chain, resulting in cessation of cellular respiration and rapid death

Answer 2

Cyanide
(cyanide poisoning can result from exposure to the poison through the production of CN- from drugs such as nitroprusside. Victims often have the smell of “bitter almonds” on their breath)

Question 3

this condition results from the uncoupling of oxidative phosphorylation from electron transport, resulting in excess heat production in genetically susceptible individuals exposed to inhaled anesthetics

Answer 3

Malignant hyperthermia
(this potentially lethal disorder is most commonly associated with exposure to halothane in patients with mutations in the ryanodine receptor of the sarcoplasmic reticulum)

Question 4

this enzyme is important in hydroxylation reactions for the detoxification of many drugs in the liver as well as being implicated in converting potential carcinogens into more active forms

Answer 4

Cytochrome P450
(this enzyme is related to the cytochromes instrumental in the electron transport chain and is found within the smooth endoplasmic reticulum, the site of drug detoxification; it is also instrumental in the formation of cholesterol and its derivatives)