Eye Flashcards
acute angle closure glaucoma presentation
red eye mid dilated nonreactive pupil, decreased peripheral vision, light halos around objects, HA, severe eye pain (periorbital eye pain and ipsilateral HA), N/V
can feel increased firmness over globe with gentle palpation.
medications that precipitate attack: anticholinergics, antihistamines, diuretics, antidepressants and SSRI’s.
treat with topical pilocarpine.
Diabetic retinopathy is caused by? and characteristic findings are:
diabetic for years and has blurred vision with partial or total loss of vision or floaters
chronic digoxin toxicity
changes in color vision, scotomas or blindness
Sudden loss of vision differential
painful or non painful
consider GPA if >50;
optic neuritis if <50
central retinal artery occlusion
acute angle closure glaucoma (but will see eye pain too)
non artertic anterior ischemic optic neuropathy
retinal detachment - see peripheral vision then central with showers of floaters.
age related macular degeneration definition and caused by:
chronic oxidative damage to the retinal pigment epithelium and chriocapillaris
risk factors for age related macular degeneration
advanced age, smoking, family history
most common leading cause of blindness in developed countries
age related macular degeneration
fundoscopy shows what in pts who have dry acute macular degeneration
drusen deposits - they represent areas of retinal depigmentation.
Dry AMD can progress to
wet acute macular degeneration which presents with acute vision loss (Days to weeks) and metamorphosia (distortion of straight lines) due to subretinal hemorrhage and fluid accumulation
how to treat moderate to severe AMD (Dry or wet)
smoking cessation (prevents disease progression) and should get daily antioxidant vitamins and zinc as this can reduce the progression to severe AMD and lower the likelihood of developing vision loss in the good eye.
Wet acute macular degeneration can be treated w/
specific treatment with vascular endothelial growth factor (VEGF) inhibitors (ranibizumab or bevacizumab) to reverse or stabilize vision loss.
drusen deposits are:
Seen in Dry form of AMD, and this accumulates between the retina and the choroid and sometimes can lead to retinal detachment.
It’s also a pigment abnormalities on fundscopy that can be seen with age related macular degeneration. Peripheral vision is spared.
what is the first thing that people who have AMD and are smokers should do?
smoking cessation counseling Helps prevent disease progression
pts with moderate to severe AMD (dry our weight) should also get
antioxidant vitamins and zinc- may reduce risk for progression to severe AMD and lowers likelihood of developing vision loss in good eye
Treatment of WET AMD
needs specific treatment with vascular endothelial growth factor (VEGF) inhibitors (like bevacizumab or ranibizumab) for treatment to stabilize or reverse vision loss.
viral conjunctivitis presentation
self limiting condition from adenovirus
presents with acute unilateral conjunctival erythema and watery discharge in the setting of URI
diagnosis of viral conjunctivitis?
clinical diagnosis with supportive (cold compresses over eyelides and topical decongestants). need good hand hygiene to prevent viral spread. no need for abx
What is olopatadine?
H1 antagonist used in treatment of allergic conjunctivitis and see chronic bilateral conjunctivits worse in the AM in pollen heavy seasons.
keratoconjunctivitis
cornea and conjunctiva are inflammed from viruses and bacteria.
severe condition with decreased visual acuity and limited ability to open eyes due to intense foreign body sensation.
Needs urgent ophthalmological evaluation to prevent vision loss.
may also feel like “sandpaper” feeling in eyes (can be seen with SLE or Sjogren’s syndrome too)
Different eye complaints (chart)
risk factors for retinal detachment
myopia
eye trauma or recent surgery (more commonly cataract surgery rather than LASIK),
advanced age,
smoking,
hypertension,
diabetic retinopathy
family history of retinal detachment
show pigmented vitreous cells behind the lens, vitreous debris and a fibrous ring due to cells normally under the retina and being liberated into the vitreous.
retinal detachment.
Need fundoscopic exam of other eye to make sure there’s no additional retinal detachment in that other eye.
Posterior vitreous detachment only = supportive care is needed
for retinal hole or horsehoe retinal tear without teachement- laser retinoplexy or cryoretinopexy is performed
how to treat true retinal detachment
retinal detachment without retinal breaks or tears can be treated conservatively but still needs an ophthalmologist to make this.
emergent intervention is needed to avoid complete vision loss. Potential options include laser cryoretinopexy or penumatic retinopexy or scleral buckle or victrectomy.
Note: direct funduscopy has low sensitivity for retinal detachment nad may be normal
Detection is based on identification of visual field deficits.
someone develops acute painless vision loss and fundoscopic exam shows a cherry red spot and pale optic disc. smoker
central retinal artery occlusion.
see the cherry red spot on macula
sudden loss of vision to one eye upon awaking. See a small cup to disc ratio with a pale disc that later becomes edematous
ischemic optic neuropathy
chart for conjunctivitis
pink eye is also known as
viral conjunctivitis
See adenovirus as a cause and associated with URI. See redness irritation (gritty sensation), scant watery discharge. See it begin unilaterally but bilateral eye involvement can happen within 48 hrs of onset of symptoms.
how long does viral conjunctivitis last for?
1-2 weks and are self limited and management is directed at reducing patient discomfort. Topical antihistamines and ocular decongestants can reduce symptoms and moist compresses also help provide comfort. No tx shortens duration of symptoms.
when to use topical eye antibiotics?
bacterial conjunctivitis (erythromycin or trimethoprim/polymixin). Bacterial conjunctivitis is assocaited with significant ocular pain and purulent discharge that rapidly reappears after being wiped away. Has stuck shut in AM.
indications for opthalmological evaluation in an acute red eye syndrome
loss of visual acuity or impaired vision,
hyphemia or hypopyon (red or white cells respectively layered in the anterior chamber),
suspected bacterial keratitis (contact lens user with pain, photophobia, and foreign body sensation),
angle closure glaucoma (headache, vomiting hazy cornea, fixed pupil)
iritis (photophobia erythematous flush around iris).
amaurosis fugax
temporary vision loss without changes in color vision or photophobia
this is with TIA
temporary bluish vision changes
phosphodiesterase 5 inhibitor side effect`(sildenafil)
central retinal artery occlusion causes
carotid artery atherosclerosis (most common)
cardiogenic emboli
small artery disease due to diabetes or HTN
carotid artery dissection
sickle cell or hypercoaguability
vasculitis (giant cell arteritis)
painless acute vision loss in one eye
complete or relative afferent pupillary defect
retinal whitening or red cherry spot in macula on funduscopy
presentation of central retinal artery occlusion
Treatment of central retinal artery occlusion
urgent opthalmology consult (permanent damage can happen in 90-100 minutes)
lower intraocular pressure (ocular massage) or anterior chamber paracentesis or IV acetazolamide or mannitol)
possible intraarterial thrombolytics
long term atherosclerosis risk factor modification
who gets central retinal artery occlusion (CRAO)
<0.1% of the population gets this and affects ppl >60 yrs, with HTN, DM2 and smoking.
pt with acute painless and severe vision loss in one eye. Has complete or relative afferent pupillary defect.
central retinal artery occlusion and see retinal whitening and cherry red spot. Need to rule out GCA
Opthalmological emergency
pt is slumped over from severe eye pain, and has vision loss.
Complains of headache, nausea, and vomiting and see light halos. See conjunctival redness (ciliary flush) and poorly reactive dilated pupil or mid dilation fixed pupil. No discharge.
acute angle closure glucoma
call opthalmology- optic atrophy and permanent vision loss can occur in a few hours without tx. If unable to see eye doctor within hour try to treat with topical pilocarpine and other intraocular pressure lowering agents (Timolol or apraclonidine)
Precipitated by exposure to sympathomimetic and anticholinergic drugs. Seen more in Asian people.
painless vision loss in one eye usually on awakening. seen in pts >50 yrs. visual exam shows afferent pupillary defect and fundoscopy shows papilledema. NO cherry spots
non arteritic anterior ischemic optic neuropathy- see loss of blood flow to the optic nerve - due to hypoperfusion or nocturnal hypotension or vasospasm.
Syndrome causes vision loss without eye pain. See some diffuse optic nerve edema or sector optic nerve edema.
pt presents with acute or subacute painful vision loss of one eye, color desaturation and headache and pain with eye movement and afferent pupillary defect. Patient is <50 yrs old
optic neuritis - inflammatory demyelination of optic nerve that can be a presenting symptom for MS.
Fundoscopic exam can be of papilledema.
what is this?
Papilledema (optic disc swelling) - sign of increased intracranial pressure ( brain ascess, infection, tumor, trauma), can be seen with optic neuritis, non artertiic anterior ischemic optic neuropathy,
progressive, painless monocular vision loss with central scotomas
this is age related macular degeneration AMD. See central scotomoas (loss of center of the visual field)
AMD is major cause of blindnes and visual impiarment in adults >50 yrs.
There’s wet and dry versions.
presentation of hypertensive retinopathy of eye
gradual painless, binocular vision loss, headaches, although pts may have no visual symptoms initially.
what do we see on fundoscopy of hypertensive retinopathy (besides those listed) ?
see copper and silver wiring, hard exudates, flame hemorrhages and AV nicking and arteriolar narrowing and ischemic changes (“cotton wool spots”)
acute vision loss asociated with flashes of light (photopsia) and numberous floaters (drifting spots or strings in visual field and eye heaviness)
can see a veil or curtain drawn over their field of vision and both peripheral and central vision is affected
Retinal detachment.
Example of vision loss
Chart of changes seen in acute glaucoma with optic disc to cup ratio
what causes uveitis?
most cases are idiopathic but secondary causes are:
infections: toxoplasmosis, CMV, syphilis
Autoimmune: Behcet’s dx, anklyosing spondylitis, IBS, sarcoidosis, reactive arthritis, microscopic colitis.
Medications: rifabutin and cidofovir
Conditions of “red” eye
what in pt history should make you concerned for urgent opthalmological evaluation in an acute red eye syndrome
impaired vision,
inability to open eye due to foreign body sensation,
photophobia,
significant eye pain,
diminished pupil reactivity
presence of corneal opacity
acute anterior uveitis syndrome presentation
See red eye, pain, decreased vision, white and yellowish discharge at base of anterior chamber and normal pupil response.
younger person and needs urgent opthalmological referral
anterior uveitis presentation
what to look for on the physical exam?
see unilateral eye pain, (red) conjunctivitis, miotic pupil and seen with vision loss and photophobia.
Inflammation can affect the anterior (ris and ciliary body) and posterior (choroid) uveal tract with adjacenet structures like the retina and vitreous humor.
Gross exam: look for ciliary flush or marked red ring around iris. Can see hypopyon (seen on other side) or leukocyte exudate in anterior chamber. Leukocytes in anterior chamber is diagnostic of anterior uveitis and differentiates it from other causes of red eye.
Anterior chamber flare - common manifestation and is created by extravasated protein that causes dispersal of light on the slit lab. Need ophthalmological exam.
Management of corneal abrasion
Name the acute causes of painful vision loss
what are some changes we see on fundoscopic exam in papilledema?
what to see on fundoscopic exam when pt who presents with chronic pulsatile headache exacerbated by lying flat and improved by sitting up.
Also can hear a whoosing wind like tinnitus.
What do they have?
They have idiopathic intracranial hypertension or pseudotumor cerebri.
See papilledema
they can also complain of blurry vision, vision loss, or horizontal binocular diplopia.
Difference between episcleritis and scleritis chart
episcleritis - inflammation of the superficial scleral vessels. see inflammation of the white of the eye without involvement of the uveal tract (iris, ciliary body or choroid). Causes mild irritation and foreign body sensation.
scleritis - inflammation of the deep scleral vessels; can be vision threatening and lead to thinning of sclera and perforation. see dark red sclera
Keratitis (corneal inflammation can occur and this is ulcerative and occurs at the periphery of cornea)
most common eye complaint of RA is dry eyes
What is episcleritis and what is it’s presentation?
What causes it?
Episcleritis is acute inflammation of the white of the eye without involvement of the uveal tract (iris, ciliary body, choroid).
Presents as redness, tearing of the eye and feel a foreign body sensation and mild irritation.
idiopathic
who gets episcleritis?
seen in young and middle aged women
self limited with most attacks resolving in about 3 weeks and this is idiopathic in nature.
If it reoccurs, then need to think about systemic dx like rheumatoid arthritis and management is with topical lubricants.
Topical or oral NSAIDS can be used for persistent symptoms.
bacterial conjunctivitis presents with
ocular pain, mucoid purulent discharge and crusting and see conjunctival redness.
Tx with topical antibiotics like erythromycin
What is scleritis?
How does this present?
how is this different from episcleritis?
Scleritis is an eye condition seen with active systemic rheumatological dx. Episcleritis is less severe and seen without dark red sclera, self limited
Presents: significant pain, visual impairment, dark red sclera (in contrast to bright red of episcleritis) and scleral edema are classic.
Manifestations generally progress (worsening pain) over days to weeks.
This a dangerous eye condition seen systemic rheumatological dx
Nuclear cataract
see rapidly reduced distance vision
- often termed myopic shift and this is early common early effect of nuclear cataract formation due to increased thickness at the center of the lens and a change in dioptric power
Myopic shift happens before visible opacification of the lense and other findings (glare, halos around lights and loss of red reflex) and this is why someone can have a normal dilated eye examination 6 months
what is allergic conjunctivitis?
see bilateral eye involvement, clear discharge, morning crusting and mattering of lids and seen with conjunctivits of any cause but significant itching.
seen with other allergic symptoms and occur due to pollen and sporadic (due to animal dander pattern. Patients with other atopic dxes are high risk
conjunctivitis that is unilateral (initially) and purulent discharge
bacterial conjunctivitis
what is this?
hordelum - acute obstruction of the meibomian gland, eyelash follicle, or lid margin tear gland and associated with inflammation and possible staph infection. Not an infection of the globe itself.
non infectious causes of anterior uveitis are treated with
topical steroids. Needs to get a opthalmological exam.
what is a drug induced optic neuropathy?
can have peripheral and optic neuropathy may be irreversible possible due to mitochondrial toxicity.
guidelines recommend no more than 28 days of linezolid therapy with a weekly CBC to monitor for possible bone marrow suppression
need periodic eye and neurological examinations are recommended in pts requiring >4 weeks of linezolid.
need to discontinue linezolid if this happens.
