Extracellular microbes

Question 1

barriers to microbial penetration

Answer 1

mucus skin, lsyozyme, lactoferrin spermine, acid pH

Question 2

these are considered extracellular microbes

Answer 2

baceteria, virus, parasite(dependng on stage of life cycel) any microbe prior to entry to cell

Question 3

Cells of innate immunity

Answer 3

Monocytes/macrophages, neutropihls, NK cells, Mast cells, basopihls, dendritic cells

Question 4

systems and molecules of innate immunity

Answer 4

complement, cytokines, defense molecules

Question 5

C5a leads to

Answer 5

mast cell degranulation which leads to release of histamine which leads to translocate p selectin to cell surface on vascular endothelial cells and to increase vascular permability

Question 6

activated vascular endothelium expresses

Answer 6

• -De novo p-selectin(histamine), E selectine(IL-1, TNF) which bind molecules on leukocytes
• -De novo ICAM1, VCAM1, upregulates ICAM1 (TNF, IL-1) which are compliments for circulationg luekocytes VLA-4, LFA-1

Question 7

VLA-4 is made of

Answer 7

CD49d and CD29

Question 8

LFA -1 is made up of

Answer 8

CD11a and CD18

Question 9

Endothelial cells also secrete

Answer 9

MCP-1(CCL2) and IL8(CXCL8

Question 10

matrix metalloproteinases degrade

Answer 10

the basement membrane and matrix

Question 11

recruited cells squeeze

Answer 11

in between endothelial cells(diapedesis)

Question 12

Diapedesis requires

Answer 12

PECAM-PECAM interaction to pull celsl through into tissues