Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

GM-CSF

A

GRANULOCYTE-MONOCYTE colony stimulating factor Source: Monocyte, Fibroblasts, Endothelial Cells, T cells Target: Myeloid progenitor Role: -differentiation of a myeloid progenitor to a GM progenitor in hematopoiesis -enhances dendritic cell maturation, proliferation and migration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

M-CSF

A

Monocyte colong stimulating factor

Source: monocyte, Fibroblasts, Endothelial cells.

Target: GM Progenitor

Role: Differentiation of a GM progenitor to a monocyte in hematopoeises. assist in migration of precursors of Dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

G-CSF

A

Granulocyte Colony stimulating factor Source: Monocyte, Fibroblasts, Endothelial cells Target: GM progenitor Role: differentiation of a GM-progenitor to a granulocyte in hematopoeisis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cytokines and Monocyte differentiation pathway

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IL-1

A

source: macrophages

Target: Monocytes, Vascular endothelium, Thp

Role:

plays a role in differentiation to macrophaged

inflammation esp with TNF

differentation of Thp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-2

A

Source: Thp, Th0 Th1

Target: Tcells expressing IL-2R

Role:helps change Th0 to Th1

Growth factor for T-cells expressing IL-2R(Thp, Th0, Th1, pCTL) (leads to clonal expansion)

differentiation of pre-CTL to CTL with IFN gamma

high concentration can convert NK cells to LAK cells that are potent klllers of tumor cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IL3

A

Source: activated T-cells

Target: Basophils, Pluripotent progenitors cells

Role: assists in differentiation of pluripotent cell to lympoid and GM progenitor. helps basophils mature in bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IL-4

A

Source: Th2 cells, Th0, Basophils, Mast Cells.

Role: Down regulate iNOS

required to isotype switch to IgE

Down regulation of Th1 cytokines

polarizes differentiation of Th0 to Th2

Used to induce in vitro differentiation of Dendritic cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IL-5

A

Source: Th2, Mast Cells, Basophils

Target: Eosinophils

Role: differentiates and assists migration of Eosinophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IL-6

A

Source, Macrophage, Th2

Target: hepatocyte, Thp, TH2

Role:

binds to cognate receptors on hepatocytes which leads to secreation of C-reactive protein (CRP)

plays a role in differentation of Thp to Th17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IL 7

A

Source: thymus, bone marrow?

differentiates Lymphoid progenitor to NK cell.

Plays a role in Central tolerance by helping selecte t-cells that are reactive to foreign peptides and not self peptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

IL 10

A

Source: Th2 cells

Role: downregulate iNOS

downregulates IL-12 secretion by APC’s (dendritic cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

IL-12

A

Source:Dendritic cells, Macrophages

Target: NK cells

Role:

Activates NK cells to secrete IFN gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IL-15

A

Source:epithelial and fibroblast cell lines, activated by monocytes/macrophages and dendritic cell.

Target: NK cells

Role: enhances IFN gamma induced by IL-12

shares many bio activites with IL 2

signals via VD 132 and CD122

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IL-17

A

Source: Th17

Target:

Role: Proinflammatory cytokine IL-6, GM, CSF, G CSF

inducle IL 8

induce metalloproteinases

IL17 a is chemotactic for neutrophils

fungal infections

autoimmune disorders if Th17 is specific for antigen.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IL-18

A

Source: mono cytes, macrophages, dendritic cells, and several non immune cells.

Target: NK Cells

Role: enhances IFN Gamma induced by IL-12

17
Q

IL-21

A

Source: Th17 cells

Target: Th17 cells

Role: acts as a growth factor for these cells

Pro inflammatory cytokine

18
Q

IL-22

A

Souce: TH17

Target:

Role, Proinflammatory cytokine

19
Q

Il-23

A

Source: Dendritic Cells, APC’s and Macrophages

Target: Th17

Role : stabilization of Th17 during differnetation of Thp cells

elevated in MS, psioraxis, Crohn’s

is a proinflammatory cytokine

20
Q

TNF

A

Source: Macrophages(autocrine and paracrine), Secreted by Th1 cells (main producer

Target: phagocyte

Role: Enhances NADPH activity, iNOS activation

21
Q

TGF Beta

A

Source: Th2

Target: Thp, Phagocytes

Role:

differentiation of Thp to a/iTregs

in presence of IL-1/6/23 plays role in differentiation of Thp to Th17

Down regulates iNOS

22
Q

IL-1 and TNF

A

Target: macrophages, vascular endothelium, hypothalamus

Role:

lowering blood pressure leading to shock

enhances secretion of cytokines and chemokines by macrophages

induces vascular endotelium to secerete IL-8, (CXCL8) and MCP-1 (CCL2)

Induces de novo expression of VCAM-1 ICAM-1 and E selectin

upregulates expression of ICAM2

induces fever through hypothalamus

23
Q

CD200R

A

ligation of CD200R results inhibition.

it is expressed primarily on myeloid cells but also on a subset of T cells.

24
Q

IFN-Gamma

A

Source: NK cells Th0 Th1 cells(main Producer) CD4+

Role: enhances NADPH activity, activates iNOS

NK-secreted IFN gamma polarizes differentiation of Th0 to Th1

Down regulates production of Th2 cytokines

differentiation of pre-CTL to CTL(with IL-2)

upregulates MHC class 1 on nucleated cells and class 2 on APCs

is a type 2 interferon

25
Q

IFN Alpha/beta

A

Secreted by virally infected cells, binding of this cytokine to neighboring cells prevents productive viral infection in those cells.

upregulate Calss I MHC

inhibit T cell proliferation

decrease in one B cell population

therapy for hairy cell leukemia, genital warts, kaposi’s sarcoma, MS, hep b/c

26
Q

FLT3

A

Source:

Target hematopoeitic cells,

Role: stimulates proliferation of hematopoietic cells

assist in migration of precursors of Dendritic cells

27
Q

IL 33

A

source: endothelial or epithelial cells as a result of trauma or necrosis
target: Mast cells
role: upregulated in parasite infections, member of alarmin family,

Dysregulated IL-33 contributes to asthma and IBD

Immunology (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions