extracellular matrix Flashcards
basement membrane: recall the definition of, explain the function of, and list the major components of the basement membrane
1
Q
define basement membrane
A
basal lamina type of extracellular matrix; flexible, thin mats
2
Q
basement membrane location
A
surround muscle, peripheral nerves and fat cells; underlie epithelia
3
Q
basement membrane functions
A
highly selective filter (e.g. glomerulus)
4
Q
diabetic nephropathy
A
extracellular matrix accumulation at glomerulus, impinging on capillary and reducing renal function, leading to renal failure
5
Q
Alport syndrome
A
basement membrane abnormally split
6
Q
structure of basement membrane
A
caveolae, lipid bilayer, glycoprotein network (e.g. laminin), collagen fibrils (e.g. type IV), integrin (receptor)
